Structure-activity relationship (SAR)of parthenin analogues with pro-apoptotic activity: Development of novel anti-cancer leads (Record no. 46822)

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fixed length control field 01537nam a2200337Ia 4500
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control field MX-MdCICY
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control field 20250625153901.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-12615
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Title Structure-activity relationship (SAR)of parthenin analogues with pro-apoptotic activity: Development of novel anti-cancer leads
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Volume/sequential designation Bioorganic & Medicinal Chemistry Letters, 19(15), p.4394-4398, 2009
520 3# - SUMMARY, ETC.
Summary, etc. Analogues of parthenin were synthesized by substitutions at different reaction centres to establish a structure-activity relationship (SAR). Some of the molecules have displayed significant cytotoxicity in human cervical carcinoma (HeLa)and human myeloid leukemia (HL-60)cells. A few of the compounds also induced apoptosis in HL-60 cells measured in terms of sub-Go/G1 DNA fraction. Also one of the lead molecules has been shown to be the inhibitor of both telomerase and topoisomerase-II.
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Topical term or geographic name entry element CYTOTOXICITY
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Topical term or geographic name entry element APOPTOSIS
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Topical term or geographic name entry element TOPOISOMERASE-II
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Topical term or geographic name entry element TELOMERASE
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Topical term or geographic name entry element SAR
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Topical term or geographic name entry element PARTHENIN
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Personal name Shah, B.A.
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Personal name Kaur, R.
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Personal name Gupta, P.
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Personal name Kumar, A.
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Personal name Sethi, V.K.
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Personal name Andotra, S.S.
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Personal name Singh, J.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Singh, J.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Taneja, S.C.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1npSfPkTsDm20z3wr4KuqSBTBH-xCQRuB/view?usp=drivesdk">https://drive.google.com/file/d/1npSfPkTsDm20z3wr4KuqSBTBH-xCQRuB/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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Source of classification or shelving scheme Clasificación local
Koha item type Documentos solicitados
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-12615 25.06.2025 25.06.2025 Documentos solicitados