Identification of optimal molecular size of modified Aloe polysaccharides with maximum immunomodulatory activity (Record no. 46837)

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control field 20250625153902.0
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-12630
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Title Identification of optimal molecular size of modified Aloe polysaccharides with maximum immunomodulatory activity
490 0# - SERIES STATEMENT
Volume/sequential designation International ImmunoPharmacology, 5(2), p.271-279, 2005
520 3# - SUMMARY, ETC.
Summary, etc. Polysaccharides isolated from the gel of Aloe species have been known to have diverse biological activities, including immunomodulatory and antitumor activities. The molecular size-immunomodulatory activity relationship of modified Aloe polysaccharide (MAP)was examined in this study. Crude MAP (G2E1)was prepared from the gel of Aloe vera that was partially digested with cellulase. Proteins in crude MAP were removed by passage through a DEAE-Sephacel column, and then the protein-free MAP (G2E1D)was further separated into three fractions, G2E1DS3 molecular weight (MWz400 KDa), G2E1DS2 (5 KDaVMWV400 KDa), G2E1DS1 (MWV5 KDa), by Sephacryl column chromatography and ultrafiltration. Immunomodulatory activities of MAP preparations were examined on a mouse macrophage cell line, RAW 264.7 cells, and in ICR strain of mouse implanted with sarcoma 180 cells. We found that polysaccharides between 400 and 5 KDa exhibit the most potent macrophage-activating activity as determined by increased cytokine production, nitric oxide release, expression of surface molecules, and phagocytic activity. In accordance with the in vitro activity, polysaccharides between 400 and 5 KDa also exhibited the most potent antitumor activity in vivo.
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element ALOE VERA
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element POLYSACCHARIDE
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element MACROPHAGE ACTIVATION
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element ANTITUMOR ACTIVITY
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Sun-A Im
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Sun-Tack Oh
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Sukgil Song
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Mi-Ran Kim
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Dong-Seon Kim
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Sung-Sick Woo
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Tae Hyung Jo
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Tae Hyung Jo
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Chong-Kil Lee
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1BN4CcC6a5nmxM95hZAq-jS3Xyd6iEDJ4/view?usp=drivesdk">https://drive.google.com/file/d/1BN4CcC6a5nmxM95hZAq-jS3Xyd6iEDJ4/view?usp=drivesdk</a>
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-12630 25.06.2025 25.06.2025 Documentos solicitados