Interaction of embryonic cortical neurons on nanofibrous scaffolds for neural tissue engineering (Record no. 46844)

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control field MX-MdCICY
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control field 20250625153903.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-12637
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Title Interaction of embryonic cortical neurons on nanofibrous scaffolds for neural tissue engineering
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Volume/sequential designation Journal of Neural Engineering, 4(2), p.35-41, 2007
520 3# - SUMMARY, ETC.
Summary, etc. The interaction of murine embryonic cortical neurons on randomly orientated electrospun scaffolds of poly(L-lactide)(PLLA)and poly(lactide-co-glycolide)(PLGA)is investigated in this study. The scaffolds were surface treated with different concentrations of KOH to partially hydrolyze the surface and therefore change the surface tension. Hydrophilicity did not significantly influence the number of primary and secondary branches; however, it had a considerable effect on neurite extension. For scaffolds with surface tensions of 40- 47 dyn cm.1 there was a significantly greater overall neurite length for both the primary and secondary branches compared with more hydrophilic scaffolds. Another major finding of this work was that the interfibre distance influenced how the neurites extended. When the interfibre distance was greater than approximately 15 ìm the neurites followed the fibres and avoided regions of very high fibre density. At interfibre distances less than approximately 15 ìm, the neurites traversed between the fibres. Therefore, this study provided little evidence that contact guidance was the dominating cue in directing neurite extension, instead inferring that chemical cues, possibly from adjacent neurons had induced directional change.
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Personal name Nisbet, D.R.
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Personal name Pattanawong, S.
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Personal name Ritchie, N.E.
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Personal name Shen, W.
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Personal name Finkelstein, D.I.
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Personal name Horne, M.K.
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Personal name Forsythe, J.S.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1zWZO-elmhSM727wuRCbXAVsGfp5qVHP8/view?usp=drivesdk">https://drive.google.com/file/d/1zWZO-elmhSM727wuRCbXAVsGfp5qVHP8/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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Source of classification or shelving scheme Clasificación local
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-12637 25.06.2025 25.06.2025 Documentos solicitados