Epigenetics in Women's Health Care (Record no. 46864)

MARC details
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fixed length control field 02467nam a2200253Ia 4500
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control field MX-MdCICY
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control field 20250625153904.0
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Transcribing agency CICY
090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN)
Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-12657
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245 10 - TITLE STATEMENT
Title Epigenetics in Women's Health Care
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Volume/sequential designation Mount SINAI Journal of Medicine, 77(2), p.225-235, 2010
520 3# - SUMMARY, ETC.
Summary, etc. Epigenetics refers to structural modifications to genes that do not change the nucleotide sequence itself but instead control and regulate gene expression. DNA methylation, histone modification, and RNA regulation are some of the mechanisms involved in epigenetic modification. Epigenetic changes are believed to be a result of changes in an organism's environment that result in fixed and permanent changes in most differentiated cells. Some environmental changes that have been linked to epigenetic changes include starvation, folic acid, and various chemical exposures. There are periods in an organism's life cycle in which the organism is particularly susceptible to epigenetic influences; these include fertilization, gametogenesis, and early embryo development. These are also windows of opportunity for interventions during the reproductive life cycle of women to improve maternal-child health. New data suggest that epigenetic influences might be involved in the regulation of fetal development and the pathophysiology of adult diseases such as cancer, diabetes, obesity, and neurodevelopmental disorders. Various epigenetic mechanisms may also be involved in the pathogenesis of preeclampsia and intrauterine growth restriction. Additionally, environmental exposures are being held responsible for causing epigenetic changes that lead to a disease process. Exposure to heavy metals, bioflavinoids, and endocrine disruptors, such as bisphenol A and phthalates, has been shown to affect the epigenetic memory of an organism. Their long-term effects are unclear at this point, but many ongoing studies are attempting to elucidate the athophysiological effects of such gene-environment interactions.
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element EPIGENETICS
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element IMPRINTED GENES
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Topical term or geographic name entry element PLACENTA
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Personal name Pozharny, Y.
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Personal name Lambertini, L.
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Personal name Clunie, G.
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Personal name Ferrara, L.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Lee, M.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/18NWJSdn9omiI7UJyM0Dgp-SDqSWyQdr6/view?usp=drivesdk">https://drive.google.com/file/d/18NWJSdn9omiI7UJyM0Dgp-SDqSWyQdr6/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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Source of classification or shelving scheme Clasificación local
Koha item type Documentos solicitados
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-12657 25.06.2025 25.06.2025 Documentos solicitados