The C-Terminal Domain of RNA Polymerase II Is Modified by Site-Specific Methylation (Record no. 46887)
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| fixed length control field | 01732nam a2200253Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625153905.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-12680 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | The C-Terminal Domain of RNA Polymerase II Is Modified by Site-Specific Methylation |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | Science, 332(6025), p.99-103, 2011 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | The carboxy-terminal domain (CTD)of RNA polymerase II (RNAPII)in mammals undergoes extensive posttranslational modification, which is essential for transcriptional initiation and elongation. Here, we show that the CTD of RNAPII is methylated at a single arginine (R1810)by the coactivator-associated arginine methyltransferase 1 (CARM1). Although methylation at R1810 is present on the hyperphosphorylated form of RNAPII in vivo, Ser2 or Ser5 phosphorylation inhibits CARM1 activity toward this site in vitro, suggesting that methylation occurs before transcription initiation. Mutation of R1810 results in the misexpression of a variety of small nuclear RNAs and small nucleolar RNAs, an effect that is also observed in Carm1-/- mouse embryo fibroblasts. These results demonstrate that CTD methylation facilitates the expression of select RNAs, perhaps serving to discriminate the RNAPII-associated machinery recruited to distinct gene types. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sims Iii,R.J. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rojas, L.A. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Beck, D. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Bonasio, R. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Schüller, R. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Drury Iii, W.J. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Eick, D. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Eick, D. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/1CGAobeofFYJ8Zv-Ha8vaBMBE0mOStCHC/view?usp=drivesdk">https://drive.google.com/file/d/1CGAobeofFYJ8Zv-Ha8vaBMBE0mOStCHC/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-12680 | 25.06.2025 | 25.06.2025 | Documentos solicitados |