Genome-wide mapping of Arabidopsis thaliana origins of DNA replication and their associated epigenetic marks (Record no. 46889)
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| fixed length control field | 01937nam a2200301Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625153905.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-12682 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | Genome-wide mapping of Arabidopsis thaliana origins of DNA replication and their associated epigenetic marks |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | Nature Structural & Molecular Biology, 18, p.395-400, 2011 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | Genome integrity requires faithful chromosome duplication. Origins of replication, the genomic sites at which DNA replication initiates, are scattered throughout the genome. Their mapping at a genomic scale in multicellular organisms has been challenging. In this study we profiled origins in Arabidopsis thaliana by high-throughput sequencing of newly synthesized DNA and identified ~1,500 putative origins genome-wide. This was supported by chromatin immunoprecipitation and microarray (ChIP-chip)experiments to identify ORC1- and CDC6-binding sites. We validated origin activity independently by measuring the abundance of nascent DNA strands. The midpoints of most A. thaliana origin regions are preferentially located within the 5_O half of genes, enriched in G+C, histone H2A.Z, H3K4me2, H3K4me3 and H4K5ac, and depleted in H3K4me1 1 and H3K9me2. Our data help clarify the epigenetic specification of DNA replication origins in A. thaliana and have implications for other eukaryotes. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Costas, C. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sanchez, M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Stroud, H. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Yu, Y. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Oliveros, J.C. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Feng, S. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Benguria, A. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Benguria, A. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Zhang, X. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Solano, R. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Jacobsen, S.E. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Gutierrez, C. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/1J7YDYNbMLA6RRqUOEeyZkSlkpqYQXSAU/view?usp=drivesdk">https://drive.google.com/file/d/1J7YDYNbMLA6RRqUOEeyZkSlkpqYQXSAU/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
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| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-12682 | 25.06.2025 | 25.06.2025 | Documentos solicitados |