Genetic and epigenetic control of early mouse development (Record no. 46891)

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fixed length control field 01982nam a2200181Ia 4500
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control field MX-MdCICY
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control field 20250625153905.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-12684
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Title Genetic and epigenetic control of early mouse development
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Volume/sequential designation Current Opinion in Genetics & Development, 19(2), p.113-121, 2009
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Summary, etc. A decade after cloning the sheep Dolly, the induction of pluripotency by transcription factors has further revolutionized the possibilities of reprogramming a cell's identity, with exciting prospects for personalized medicine. Establishing totipotency during natural reproduction remains, however, exceedingly more efficient than in productive cloning or in transcription factor-based reprogramming. Understanding the molecular mechanisms directing acquisition of totipotency during early embryogenesis may enable optimization of protocols for induced reprogramming. Recent studies in mouse embryonic stem cells (ESCs)show that selfrenewal and pluripotency are efficiently maintained by a core set of transcription factors when intrinsic differentiation inducing signals are blocked. In early embryos, the specification of the pluripotent epiblast and two differentiating lineages (trophectoderm and primitive endoderm)is controlled by transcription factors that are regulated by autoactivating and reciprocal repressive mechanisms as well as by ERK-mediated signaling. Chromatin-based regulatory mechanisms also contribute to the identity of ESCs and early embryos. During gametogenesis, genomes undergo extensive epigenetic reprogramming. This may underlie the efficient acquisition of totipotency during subsequent reimplantation development.
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Personal name Mareike Albert
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Personal name Antoine Hfm Peters
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Uniform Resource Identifier <a href="https://drive.google.com/file/d/1n_L9U_1Alh1C3ieAmYHT-RFQ7Dsn47Kt/view?usp=drivesdk">https://drive.google.com/file/d/1n_L9U_1Alh1C3ieAmYHT-RFQ7Dsn47Kt/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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Source of classification or shelving scheme Clasificación local
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-12684 25.06.2025 25.06.2025 Documentos solicitados