Modulation of embryonic stem cell fate and somatic cell reprogramming by small molecules (Record no. 46903)

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control field MX-MdCICY
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control field 20250625153906.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-12696
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245 10 - TITLE STATEMENT
Title Modulation of embryonic stem cell fate and somatic cell reprogramming by small molecules
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Volume/sequential designation Reproductive biomedicine online, 21(1), p.26-36, 2010
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General note Artículo
520 3# - SUMMARY, ETC.
Summary, etc. Embryonic stem cells (ESC) are pluripotent cells and have the ability to self-renew in vitro and to differentiate into cells representing all three germ layers. They provide enormous opportunities for basic research, regenerative medicine as well as drug discovery. The mechanisms that govern ESC fate are not completely understood, so a better understanding and control of ESC self-renewal and differentiation are pivotal for therapeutic applications. In contrast to growth factors and genetic manipulations, small molecules offer great advantages in modulating ESC fate. For instance, they could be conveniently identified through high-throughput screening, work across multiple signalling pathways and affect epigenetic modifications as well. This review focuses on the recent progress in the use of small molecules to regulate ESC self-renewal, differentiation and somatic cell reprogramming.
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Topical term or geographic name entry element DIFFERENTIATION
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element EMBRYONIC STEM CELLS
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element REPROGRAMMING
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element SELF-RENEWAL
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element SMALL MOLECULE MODULATORS
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Zhang, X. Z.
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Uniform Resource Identifier <a href="https://drive.google.com/file/d/1pBUCXWZBdsegYpwWUI-kaMwUNgoWGiIh/view?usp=drivesdk">https://drive.google.com/file/d/1pBUCXWZBdsegYpwWUI-kaMwUNgoWGiIh/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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Source of classification or shelving scheme Clasificación local
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-12696 25.06.2025 25.06.2025 Documentos solicitados