Chalcones: An Update on Cytotoxic and Chemoprotective Properties (Record no. 46957)
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| 000 -LEADER | |
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| fixed length control field | 02026nam a2200253Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625153908.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-12750 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | Chalcones: An Update on Cytotoxic and Chemoprotective Properties |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | Current Medicinal Chemistry, 12(4), p.483-499, 2005 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | Chalcone is a unique template that is associated with several biological activities. In this review, an update of the cytotoxic and chemoprotective activities of chalcones is provided. Cytotoxicity against tumour cell lines may be the result of disruption of the cell cycle, inhibition of angiogenesis, interference with p53- MDM2 interaction, mitochondrial uncoupling or induction of apoptosis. Structural requirements for cytotoxi activity vary according to the mechanisms of action. For anti-mitotic activity, the presence of methoxy substituents, a-methylation of the enone moiety and the presence of 2' oxygenated substituents are favourable features. Conformational restraint of the chalcone template generally leads to a decrease in cytotoxic activity. Chemoprotection by chalcones may be a consequence of their antioxidant properties, mediated via inhibition or induction of metabolic enzymes, by an anti-invasive effect or a reduction in nitric oxide production. Hydroxyl and prenyl substituents are associated with antioxidant properties and induction of quinone reductase activities. The thiol reactivity of chalcones is likely to contribute to both cytotoxic and chemoprotective properties of these compounds. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | CHALCONES |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | CYTOTOXIC |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | CHEMOPROTECTIVE |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | ORGANIC SYNTHESIS |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | PHYSICOCHEMICAL CHARACTERISATION |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Go, M.L. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wu, X. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Liu, X.L. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/187HEi7mx9uFw2Csv0NdSuC6TPIuaqFk3/view?usp=drivesdk">https://drive.google.com/file/d/187HEi7mx9uFw2Csv0NdSuC6TPIuaqFk3/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-12750 | 25.06.2025 | 25.06.2025 | Documentos solicitados |