On the art of identifying effective and specific siRNAs (Record no. 46965)

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control field MX-MdCICY
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control field 20250625153908.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-12759
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Title On the art of identifying effective and specific siRNAs
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Volume/sequential designation Nature Methods, 3, p.670-676, 2006
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Summary, etc. Small interfering RNAs (siRNAs)have been widely exploited for sequence-specific gene knockdown, predominantly to investigate gene function in cultured vertebrate cells, and also hold promise as therapeutic agents. Because not all siRNAs that are cognate to a given target mRNA are equally effective, computational tools have been developed based on experimental data to increase the likelihood of selecting effective siRNAs. Furthermore, because target-complementary siRNAs can also target other mRNAs containing sequence segments that are partially complementary to the siRNA, most computational tools include ways to reduce potential off-target effects in the siRNA selection process. Though these methods facilitate selection of functional siRNAs, they do not yet alleviate the need for experimental validation. This perspective provides a practical guide based on current wisdom for selecting siRNAs.
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Personal name Pei, Y.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Tuschl, T.
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Uniform Resource Identifier <a href="https://drive.google.com/file/d/1TbyPMAJZKd9oK6pXKvMFIrg_smqjaotY/view?usp=drivesdk">https://drive.google.com/file/d/1TbyPMAJZKd9oK6pXKvMFIrg_smqjaotY/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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