MARC details
| 000 -LEADER |
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| fixed length control field |
02568nam a2200337Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20250625153910.0 |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
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| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
B-12807 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT |
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| Title |
Hydrophobic-Domain-Dependent Protein-Protein Interactions Mediate the Localization of GPAT Enzymes to ER Subdomains |
| 490 0# - SERIES STATEMENT |
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| Volume/sequential designation |
Traffic, 12(4), p.452-472, 2011 |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
The endoplasmic reticulum (ER)is a dynamic organelle that consists of numerous regions or 'subdomains' that have discrete morphological features and functional properties. Although it is generally accepted that these subdomains differ in their protein and perhaps lipid compositions, a clear understanding of how they are assembled and maintained has not been well established. Wepreviously demonstrated that twodiacylglycerol acyltransferase enzymes (DGAT1 and DGAT2)from tung tree (Vernicia fordii ) were located in different subdomains of ER, but the mechanisms responsible for protein targeting to these subdomains were not elucidated. Here we extend these studies by describing two glycerol- 3-phosphate acyltransferase-like (GPAT)enzymes from tung tree, GPAT8 and GPAT9, that both colocalize with DGAT2 in the same ER subdomains.Measurement of protein- protein interactions using the split-ubiquitin assay revealed that GPAT8 interacts with itself, GPAT9 and DGAT2, but not with DGAT1. Furthermore, mutational analysis of GPAT8 revealed that the protein's first predicted hydrophobic region, which contains an amphipathic helix-like motif, is required for interaction with DGAT2 and for DGAT2-dependent colocalization in ER subdomains. Taken together, these results suggest that the regulation and organization of ER subdomains is mediated at least in part by higher-ordered, hydrophobicdomain- dependent homo- and hetero-oligomeric protein- protein interactions. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
DIACYLGLYCEROL ACYLTRANSFERASE |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
ENDOPLASMIC RETICULUM |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
PROTEIN-PROTEIN INTERACTIONS |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
PROTEIN TARGETING |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
PROTEIN TOPOLOGY |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
SUBDOMAIN |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Gidda, S.K. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Shockey, J.M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Falcone, M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Kim, P.K. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Rothstein, S.J. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Andrews, D.W. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Dyer, J.M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Dyer, J.M. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="https://drive.google.com/file/d/1o_iB6eEqAvkAxPwTX8KiYKWebc_GwYQV/view?usp=drivesdk">https://drive.google.com/file/d/1o_iB6eEqAvkAxPwTX8KiYKWebc_GwYQV/view?usp=drivesdk</a> |
| Public note |
Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Clasificación local |
| Koha item type |
Documentos solicitados |
