Pancreatic Intraepithelial Neoplasia A New Nomenclature and Classification System for Pancreatic Duct Lesions (Record no. 47176)

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control field MX-MdCICY
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250625153913.0
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Transcribing agency CICY
090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN)
Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-12974
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245 10 - TITLE STATEMENT
Title Pancreatic Intraepithelial Neoplasia A New Nomenclature and Classification System for Pancreatic Duct Lesions
490 0# - SERIES STATEMENT
Volume/sequential designation The American Journal of Surgical Pathology, 25(5), p.579-586, 2008
520 3# - SUMMARY, ETC.
Summary, etc. Proliferative epithelial lesions in the smaller caliber pancreatic ducts and ductules have been the subject of numerous morphologic, clinical, and genetic studies; however, a standard nomenclature and diagnostic criteria for classifying these lesion have not been established. To evaluate the uniformity of existing systems for grading duct lesions in the pancreas, 35 microscopic slides with 35 representative duct lesions were sent to eight expert pathologists from the United States, Canada, and Europe. Kappa values for interobserver agreement could not be calculated initially because more than 70 different diagnostic terms were used by the eight pathologists. In several cases, the diagnoses rendered for a single duct lesion ranged from "hyperplasia," to "metaplasia," to "dysplasia," to "carcinoma in situ." This review therefore demonstrated the need for a standard nomenclature and classification system. Subsequently, during a working group meeting, the pathologists agreed to adopt a single standard system. The terminology pancreatic intraepithelial neoplasia (or PanIN)was elected, and diagnostic criteria for each grade of PanIN were established (http://pathology.jhu.edu/pancreas_panin). This new system was then evaluated by having the eight pathologists rereview the original 35 cases. Only seven different diagnoses were rendered, and kappa values of 0.43, 0.14, and 0.42 were obtained for PanINs 1, 2, and 3 respectively. Cases assigned other diagnoses (e.g., squamous metaplasia)collectively had a kappa value of 0.41. These results show both the potential of the classification system, and also the difficulty of classifying these lesions even with a consistent nomenclature. However, even when there is lack of consensus, having a restricted set of descriptions and terms allows a better understanding of the reasons for disagreement. It is suggested that we adopt and apply this system uniformly, with continued study of its reliability and use, and possibly further refinement. The acceptance of a standard classification system will facilitate the study of pancreatic duct lesions, and will lead ultimately to a better understanding of their biologic importance.
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Topical term or geographic name entry element PANCREAS
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element PANCREATIC
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element NEOPLASIA
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element CARCINOMA
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element IN SITU.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Hruban, R.H.
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Personal name Volkan Adsay, N.
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Personal name Albores-Saavedra, J.
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Personal name Compton, C.
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Personal name Garrett, E.S.
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Personal name Goodman, S.N.
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Personal name Kern, S.E.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Kern, S.E.
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Personal name Klöppel, G.
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Personal name Longnecker, D.S.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Lüttges, J.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Offerhaus, G.J.A.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1ciXagkw4Gd4cCoMvIRbZkv61R7qt9_ao/view?usp=drivesdk">https://drive.google.com/file/d/1ciXagkw4Gd4cCoMvIRbZkv61R7qt9_ao/view?usp=drivesdk</a>
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Source of classification or shelving scheme Clasificación local
Koha item type Documentos solicitados
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-12974 25.06.2025 25.06.2025 Documentos solicitados