Capsaicin, a Component of Red Peppers, Inhibits the Growth of Androgen-Independent, p53 Mutant Prostate Cancer Cells (Record no. 47178)

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control field MX-MdCICY
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control field 20250625153913.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-12976
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245 10 - TITLE STATEMENT
Title Capsaicin, a Component of Red Peppers, Inhibits the Growth of Androgen-Independent, p53 Mutant Prostate Cancer Cells
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Volume/sequential designation Cancer Research, 66, p.3222-3229, 2006
520 3# - SUMMARY, ETC.
Summary, etc. Capsaicin is the major pungent ingredient in red peppers. Here, we report that it has a profound antiproliferative effect on prostate cancer cells, inducing the apoptosis of both androgen receptor (AR)-positive (LNCaP)and -negative (PC-3, DU-145)prostate cancer cell lines associated with an increase of p53, p21, and Bax. Capsaicin down-regulated the expression of not only prostate-specific antigen (PSA)but also AR. Promoter assays showed that capsaicin inhibited the ability of dihydrotestosterone to activate the PSA promoter/enhancer even in the presence of exogenous AR in LNCaP cells, suggesting that capsaicin inhibited the transcription of PSA not only via downregulation of expression of AR, but also by a direct inhibitory effect on PSA transcription. Capsaicin inhibited NF-K activation by preventing its nuclear migration. In further studies, capsaicin inhibited tumor necrosis factor-A-stimulated degradation of IKBA in PC-3 cells, which was associated with the inhibition of proteasome activity. Taken together, capsaicin inhibits proteasome activity which suppressed the degradation of IKBA, preventing the activation of NF-KB. Capsaicin, when given orally, significantly slowed the growth of PC-3 prostate cancer xenografts as measured by size [75 F 35 versus 336 F 123 mm3 (FSD); P = 0.017]and weight [203 F 41 versus 373 F 52 mg (FSD); P = 0.0006; capsaicin-treated versus vehicletreated mice, respectively]. In summary, our data suggests that capsaicin, or a related analogue, may have a role in the management of prostate cancer.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Mori, A.
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Personal name Lehmann, S.
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Personal name O'Kelly, J.
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Personal name Kumagai, T.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Desmond, J.C.
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Personal name Pervan, M.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Mcbride, W.H.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Mcbride, W.H.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Koeffler, H.P.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1DsDCV9gZCmvD4CUlFvM80sP2P_QD72FE/view?usp=drivesdk">https://drive.google.com/file/d/1DsDCV9gZCmvD4CUlFvM80sP2P_QD72FE/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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Source of classification or shelving scheme Clasificación local
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-12976 25.06.2025 25.06.2025 Documentos solicitados