Nanoparticles that communicate in vivo to amplify tumour targeting (Record no. 47230)
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| 000 -LEADER | |
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| fixed length control field | 01950nam a2200277Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625153914.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-13028 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | Nanoparticles that communicate in vivo to amplify tumour targeting |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | Nature Materials, 10, p.545-552, 2011 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | Nanomedicines have enormous potential to improve the precision of cancer therapy, yet our ability to efficiently home these materials to regions of disease in vivo remains very limited. Inspired by the ability of communication to improve targeting in biological systems, such as inflammatory-cell recruitment to sites of disease, we construct systems where synthetic biological and nanotechnological components communicate to amplify disease targeting in vivo. These systems are composed of 'signalling' modules (nanoparticles or engineered proteins)that target tumours and then locally activate the coagulation cascade to broadcast tumour location to clot-targeted 'receiving' nanoparticles in circulation that carry a diagnostic or therapeutic cargo, thereby amplifying their delivery. We show that communicating nanoparticle systems can be composed of multiple types of signalling and receiving modules, can transmit information through multiple molecular pathways in coagulation, can operate autonomously and can target over 40 times higher doses of hemotherapeutics to tumours than non-communicating controls. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Von Maltzahn, G. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Park, J. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lin, K.Y. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Singh, N. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Schwöppe, C. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mesters, R. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Berdel, W.E. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Berdel, W.E. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sailor, M.J. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Bhatia, S.N. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/12iJmyGjeQtrdrFCl8ZDL7vwpEQdtfE4c/view?usp=drivesdk">https://drive.google.com/file/d/12iJmyGjeQtrdrFCl8ZDL7vwpEQdtfE4c/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
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| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-13028 | 25.06.2025 | 25.06.2025 | Documentos solicitados |