Human single-donor composite skin substitutes based on collagen and polycaprolactone copolymer (Record no. 47324)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02274nam a2200385Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625153916.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-13122 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | Human single-donor composite skin substitutes based on collagen and polycaprolactone copolymer |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | BioChemical and Biophysical Research Communications, 386(1), p.21-25, 2009 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | The development and characterization of an enhanced composite skin substitute based on collagen and poly(e-caprolactone)are reported. Considering the features of excellent biocompatibility, easy-manipulated property and exempt from cross-linking related toxicity observed in the 1:20 biocomposites, skin substitutes were developed by seeding human single-donor keratinocytes and fibroblasts alone on both sides of the 1:20 biocomposite to allow for separation of two cell types and preserving cell signals transmission via micro-pores with a porosity of 28.8 ± 16.1 lm. The bi-layered skin substitute exhibited both differentiated epidermis and fibrous dermis in vitro. Less Keratinocyte Growth Factor production was measured in the co-cultured skin model compared to fibroblast alone condition indicating a favorable microenvironment for epidermal homeostasis. Moreover, fast wound closure, epidermal differentiation, and abundant dermal collagen deposition were observed in composite skin in vivo. In summary, the beneficial characteristics of the new skin substitutes exploited the potential for pharmaceutical screening and clinical application. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | SKIN SUBSTITUTE |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | COLLAGEN |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | POLY(E-CAPROLACTONE) |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | BIOCOMPOSITE |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | KERATINOCYTE |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | FIBROBLAST |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | POROSITY |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dai, N. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Yeh, M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Chiang, C. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Chen, K. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Liu, T. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Feng, A. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Chao, L. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Chao, L. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sytwu, H. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Chen, S. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Chen, T. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Adams, E.F. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/1w3No6w8jfRCkbjHWlCN_G3GPcnXJM4Mf/view?usp=drivesdk">https://drive.google.com/file/d/1w3No6w8jfRCkbjHWlCN_G3GPcnXJM4Mf/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-13122 | 25.06.2025 | 25.06.2025 | Documentos solicitados |