Cellular uptake of polyurethane nanocarriers mediated by gemini quaternary ammonium (Record no. 47330)

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fixed length control field 02148nam a2200313Ia 4500
003 - CONTROL NUMBER IDENTIFIER
control field MX-MdCICY
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250625153916.0
040 ## - CATALOGING SOURCE
Transcribing agency CICY
090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN)
Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-13128
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245 10 - TITLE STATEMENT
Title Cellular uptake of polyurethane nanocarriers mediated by gemini quaternary ammonium
490 0# - SERIES STATEMENT
Volume/sequential designation BioMaterials, 32, p.9515-9524, 2011
520 3# - SUMMARY, ETC.
Summary, etc. The effective passage of drug formulations into tumor cells is a key factor in the development of nanoscale delivery systems. However, rapid cellular uptake with reduced toxicity remains a great challenge for efficient and safe delivery. In this study, we first use gemini quaternary ammonium (GQA)as a cell internalization promoter to enhance the cellular uptake of drug nanocarriers. It is found that a twenty times faster cell internalization could be achieved by introducing GQA into biodegradable multiblock polyurethane nanomicelles, as confirmed by flow cytometry and confocal laser scanning microscopy (CLSM)studies. Meanwhile, an added methoxyl-poly(ethylene glycol)(mPEG)outer corona could protect these cationic micelles from cytotoxicity at high concentrations, as verified by methyl tetrazolium (MTT)assay. Moreover, GQA not only acts as an enhancer for rapid cellular entry, but also plays an important role in controlled self-assembly and high drug loading capacity. Our work offers a new understanding on the role of cationic surfactants; and provides a facile and economical approach for the design of versatile drug nanocarriers to achieve efficient delivery and good biocompatibility.
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element BIODEGRADABLE MULTIBLOCK POLYURETHANE
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element NANOCARRIER
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element GEMINI QUATERNARY AMMONIUM
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element CELLULAR UPTAKE
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element DRUG DELIVERY
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Ding, M.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name He, X.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Wang, Z.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Li, J.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Tan, H.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Deng, H.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Fu, Q.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Fu, Q.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1r3UWEI6yv8wtqCh-8QlYcEJWgRpX4g1S/view?usp=drivesdk">https://drive.google.com/file/d/1r3UWEI6yv8wtqCh-8QlYcEJWgRpX4g1S/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme Clasificación local
Koha item type Documentos solicitados
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-13128 25.06.2025 25.06.2025 Documentos solicitados