MARC details
| 000 -LEADER |
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| fixed length control field |
02723nam a2200337Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20250625153917.0 |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
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| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
B-13185 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT |
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| Title |
Cyclic, mechanical compression enhances chondrogenesis of mesenchymal progenitor cells in tissue engineering scaffolds |
| 490 0# - SERIES STATEMENT |
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| Volume/sequential designation |
Biorheology, 41(3-4), p.335-3456, 2004 |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
The effects of cyclic, mechanical compression on human bone marrow-derived mesenchymal progenitor cells undergoing chondrogenic differentiation were examined in this study. Mesenchymal progenitor cells were injected into cylindrical biodegradable scaffolds (hyaluronan-gelatin composites), cultured in a defined, serum-free chondrogenic medium and subjected to cyclic, mechanical compression. Scaffolds were loaded for 4 hours daily in the first 7 days of culture. At 1, 7, 14 and 21 days of culture, scaffolds were harvested for reverse transcriptase Polymerase Chain Reaction (RT-PCR), histology, quantitative DNA, proteoglycan and collagen analysis. Scaffolds loaded for 7 days showed a significant upregulation especially of chondrogenic markers (type II collagen, aggrecan; p < 0.0001). No significant difference could be found for DNA content between loaded samples and unloaded controls. At day 1 in culture no significant differences in proteoglycan- and collagen contents could be detected between unloaded and loaded samples. After 21 days the proteoglycan (p < 0.001)and collagen contents (p < 0.0001)were significantly higher in the loaded samples compared to unloaded controls. By histological analysis (toluidine blue)a higher amount of proteoglycan-rich, extracellular matrix production throughout the matrix could be detected for loaded samples compared to unloaded controls. This study indicates that cyclic, mechanical compression enhances the expression of chondrogenic markers in mesenchymal progenitor cells differentiated in vitro resulting in an increased cartilaginous matrix formation, and suggests that mechanical forces may play an important role in cartilage repair. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
CHONDROGENESIS |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
STEM CELL |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
BONE MARROW |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
MECHANOBIOLOGY |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
COMPRESSION |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Angele, P. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Schumann, D. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Angele, M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Kinner, B. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Englert, C. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Hente, R. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Fuchtmeier, B. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Fuchtmeier, B. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Neumann, C. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Kujat, R. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="https://drive.google.com/file/d/143T4rSf1AVN9YUbw2RvDHZQRMi0zNee1/view?usp=drivesdk">https://drive.google.com/file/d/143T4rSf1AVN9YUbw2RvDHZQRMi0zNee1/view?usp=drivesdk</a> |
| Public note |
Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Clasificación local |
| Koha item type |
Documentos solicitados |
