Slow-binding inhibition: the general case (Record no. 47654)

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control field MX-MdCICY
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control field 20250625153923.0
040 ## - CATALOGING SOURCE
Transcribing agency CICY
090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN)
Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-13454
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245 10 - TITLE STATEMENT
Title Slow-binding inhibition: the general case
490 0# - SERIES STATEMENT
Volume/sequential designation Biochimica et Biophysica Acta, 1298(1), p.78-86, 1996
520 3# - SUMMARY, ETC.
Summary, etc. Two basic kinetic mechanisms have been described to account for the slow-binding inhibition of enzyme-catalyzed reactions. One mechanism involves the slow interaction of an inhibitor with enzyme (Mechanism A), while the other involves the rapid formation of an enzyme-inhibitor complex that undergoes a slow isomerization reaction (Mechanism B). But the initial interaction of enzyme and inhibitor may not necessarily be fast so that the free enzyme and the two forms of enzyme inhibitor complex are in steady-state equilibrium. This assumption would give rise to a more general form of Mechanism B. The present study has been concerned with attempts to determine whether it might be possible to distinguish between the three possible inhibition mechanisms by steady-state kinetic techniques. Tile approach to the investigation has been to derive theoretical data for the most general mechanism by using three different ratios for the two rate constants that determine which mechanism applies. The progress curve data were then fitted to the rate equations that describe the other two mechanisms. The results draw attention to the difficulties of deducing that experimental data conform to the most general mechanism. They also show how the values for the kinetic parameters, as determined from fits of the data to the equations that describe Mechanisms A and B, can be considerably in error.
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element ENZYME INHIBITION
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element SLOW BINDING
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element KINETIC MECHANISM
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element THEORETICAL ANALYSIS
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Sculley, M.J.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Morrison, J.F.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Wallace Cleland, W.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1QiWSRWPdWOK0Yy-_STRTYKyM1nJel5cy/view?usp=drivesdk">https://drive.google.com/file/d/1QiWSRWPdWOK0Yy-_STRTYKyM1nJel5cy/view?usp=drivesdk</a>
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Source of classification or shelving scheme Clasificación local
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-13454 25.06.2025 25.06.2025 Documentos solicitados