Extrachromosomal MicroDNAs and Chromosomal Microdeletions in Normal Tissues (Record no. 47738)

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control field MX-MdCICY
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control field 20250625153924.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-13539
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Title Extrachromosomal MicroDNAs and Chromosomal Microdeletions in Normal Tissues
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Volume/sequential designation Science, 336(6077), p.82-6, 2012
520 3# - SUMMARY, ETC.
Summary, etc. We have identified tens of thousands of short extrachromosomal circular DNAs (microDNA)in mouse tissues as well as mouse and human cell lines. These microDNAs are 200-400 bp long, derived from unique non-repetitive sequence and are enriched in the 5' untranslated regions of genes, exons and CpG islands. Chromosomal loci that are enriched sources of microDNA in adult brain are somatically mosaic for microdeletions that appear to arise from the excision of microDNAs. Germline microdeletions identified by the "Thousand Genomes" project may also arise from the excision of microDNAs in the germline lineage. We have thus identified a new DNA entity in mammalian cells and provide evidence that their generation leaves behind deletions in different genomic loci.
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Personal name Shibata, Y.
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Personal name Kumar, P.
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Personal name Layer, R.
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Personal name Willcox, S.
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Personal name Gagan, J.R.
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Personal name Griffith, J.D.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Dutta, A.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1ZWVRluOr11qJHk8al_Nij_kFTHDes4p5/view?usp=drivesdk">https://drive.google.com/file/d/1ZWVRluOr11qJHk8al_Nij_kFTHDes4p5/view?usp=drivesdk</a>
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Source of classification or shelving scheme Clasificación local
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-13539 25.06.2025 25.06.2025 Documentos solicitados