Lipases and esterases: a review of their sequences, structure and evolution (Record no. 47753)
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| fixed length control field | 02959nam a2200241Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625153924.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-13554 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | Lipases and esterases: a review of their sequences, structure and evolution |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | Biotechnology Annual Review, 1, p.315-371, 1995 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | This chapter aims to provide a brief review on the enzyme family of lipases and esterases. The sequences, 3D structures and pH dependent electrostatic signatures are presented and analyzed. Since the family comprises more than 100 sequences, we have tried to focus on the most interesting features from our perspective, which translates into finding similarities and differences between members of this family, in particular in and around the active sites, and to identify residues that are partially or totally conserved. Such residues we believe are either important for maintaining the structural scaffold of the protein or to maintain activity or specificity. The structure function relationship for these proteins is therefore of central interest. Can we uniquely identify a protein from this large family of sequences - and if so, what is the identifier? The protein family displays some highly complex features: many of the proteins are interfacially activated, i.e. they need to be in physical contact with he aggregated substrate. Access to the active site is blocked with either a loop fragment or an a-helical fragment in the absence of interfacial contact. Although the number of known, relevant protein 3D structures is growing steadily, we are nevertheless faced with a virtual explosion in the number of known or deduced amino acid sequences. It is therefore unrealistic to expect that all protein sequences within the foreseeable future will have their 3D structure determined by X-ray diffractional analysis or through other methods. When feasible the gene andlor the amino acid sequences will be analyzed from an evolutionary perspective. As the 3D folds are often remarkably similar, both among the triglyceride lipases as well as among the esterases, the functional diversities (e.g. specificity)must originate in differences in surface residue utilization, in particular of charged residues. The pH variations in the isopotential surfaces of some of the most interesting lipases are presented and a qualitative interpretation proposed. Finally we illustrate that NMR has potential for becoming an important tool in the study of lipases, esterases and their kinetics. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Anthonsen, H.W. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Baptista, A. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Drablprs, F. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Martel, P. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Petersen, S.B. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sebastia, M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Vaz, L. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/1STzeOQEiTGwaZMB_RQiUAi0CMe0q8TN3/view?usp=drivesdk">https://drive.google.com/file/d/1STzeOQEiTGwaZMB_RQiUAi0CMe0q8TN3/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
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| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-13554 | 25.06.2025 | 25.06.2025 | Documentos solicitados |