The challenge An update The challenge of Chagas' disease chemotherapy: An update of drugs assayed against Trypanosoma cruzi (Record no. 47905)

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control field MX-MdCICY
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control field 20250625153927.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-13707
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Title The challenge An update The challenge of Chagas' disease chemotherapy: An update of drugs assayed against Trypanosoma cruzi
490 0# - SERIES STATEMENT
Volume/sequential designation Acta Tropica, 53(2), p.83-98, 1993
520 3# - SUMMARY, ETC.
Summary, etc. The chemotherapy of Chagas' disease remains an unsolved problem, and the search for alternative drugs continues. Only two nitroheterocyclic drugs are in clinical use at the present time, and these have severely restricted applicability for chronic patients, as well as being highly toxic. This review covers drugs tested in the last 12 years. A large number of different compounds have been assayed in a variety of ways, most commonly in terms of their capacity to inhibit epimastigote proliferation. Allopurinol has emerged for the treatment of chronic cases. However, only with greater knowledge of the biochemistry of the parasiteand in particular of its peculiarities, will it be possible to shift the emphasis of drug research away from random screenings onto a more rational footing. This is exemplified by recent studies carried out using purine derivatives and trypanothione reductase inhibitors
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element TRYPANOSOMA CRUZI
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element CHAGAS' DISEASE
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Topical term or geographic name entry element CHEMOTHERAPY
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Topical term or geographic name entry element DRUGS
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name De Castro, S.L.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1lNdxKDKD0J08BAcNmLbwdlN76qpT8zp3/view?usp=drivesdk">https://drive.google.com/file/d/1lNdxKDKD0J08BAcNmLbwdlN76qpT8zp3/view?usp=drivesdk</a>
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Source of classification or shelving scheme Clasificación local
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-13707 25.06.2025 25.06.2025 Documentos solicitados