The majority of long non-stop reading flames on the antisense strand can be explained by biased codon usage (Record no. 47953)

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control field MX-MdCICY
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control field 20250625153928.0
040 ## - CATALOGING SOURCE
Transcribing agency CICY
090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN)
Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-13755
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
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245 10 - TITLE STATEMENT
Title The majority of long non-stop reading flames on the antisense strand can be explained by biased codon usage
490 0# - SERIES STATEMENT
Volume/sequential designation Gene, 194(1), p.143-155, 1997
520 3# - SUMMARY, ETC.
Summary, etc. In recent studies it has been suggested that long reading frames on the antisense strand of open reading frames (ORFs)are more frequent than expected. The vertebrate DNA database was searched for long (greater than 900 bp)antisense non-stop eading frames (aNRFs)that overlap known coding regions. The sequences obtained were predominantly positioned in DNA with a high usage of G or C in the third codon position of the sense ORF. The major class of sequences revealed by the search was that of the heat-shock protein 70 kDa (Hsp70)family. A long Hsp70 aNRF was found in many Hsp70 sequences and occurred in species as diverse as fish, flies, fungi and bacteria. The role of codon usage bias was analysed both in the specific case of the Hsp70 genes and in a general species-wide context. The data obtained showed that even the very long aNRFs present in the Hsp70 family could be explained by codon usage bias on the sense strand. Codon usage bias is determined by C content at the third codon position of the sense ORF and, in some species, by a high expression level of the gene in question. Such an explanation for the occurrence of long aNRFs cannot exclude that some aNRFs are transcribed and translated.
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element THIRD CODON POSITIONS
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element ANTISENSE
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element OPEN READING FRAME
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element HEAT-SHOCK PROTEIN 70
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element GC PRESSURE
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element GENOME COMPOSITION
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Silke, J.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1FYBsIJ2ugmTuRLdTzYdS92rQBekTtqMf/view?usp=drivesdk">https://drive.google.com/file/d/1FYBsIJ2ugmTuRLdTzYdS92rQBekTtqMf/view?usp=drivesdk</a>
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Source of classification or shelving scheme Clasificación local
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-13755 25.06.2025 25.06.2025 Documentos solicitados