MARC details
| 000 -LEADER |
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| fixed length control field |
02413nam a2200289Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20250625153929.0 |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
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| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
B-13772 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT |
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| Title |
A possible model of benzimidazole binding to b-tubulin disclosed by invoking an inter-domain movement |
| 490 0# - SERIES STATEMENT |
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| Volume/sequential designation |
Journal of Molecular Graphics and Modelling, 23(3), p.275-284, 2004 |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
Although it is well established that benzimidazole (BZMs)compounds exert their therapeutic effects through binding to helminth btubulin and thus disrupting microtubule-based processes in the parasites, the precise location of the benzimidazole-binding site on the btubulin molecule has yet to be determined. In the present study, we have used previous experimental data as cues to help identify this site. Firstly, benzimidazole resistance has been correlated with a phenylalanine-to-tyrosine substitution at position 200 of Haemonchus contortus b-tubulin isotype-I. Secondly, site-directed mutagenesis studies, using fungi, have shown that other residues in this region of the protein can influence the interaction of benzimidazoles with b-tubulin. However, the atomic structure of the ab-tubulin dimer shows that residue 200 and the other implicated residues are buried within the protein. This poses the question: how might benzimidazoles interact with these apparently inaccessible residues? In the present study, we present a mechanism by which those residues generally believed to interact with benzimidazoles may become accessible to the drugs. Furthermore, by docking albendazole-sulphoxide into a modelled H. contortus btubulin molecule we offer a structural explanation for how the mutation conferring benzimidazole resistance in nematodes may act, as well as a possible explanation for the species-specificity of benzimidazole anthelmintics. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
BENZIMIDAZOLE |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
TUBULIN |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
BENZIMIDAZOLE RESISTANCE |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
DOMAIN MOVEMENT |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
HAEMONCHUS CONTORTUS |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
FASCIOLA HEPATICA |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Robinson, M.W. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Mcferran, N. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Trudgett, A. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Hoey, L. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Fairweather, I. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="https://drive.google.com/file/d/1budK0m1C3Z4wkbC-DM4NmCxjhaXFBcn2/view?usp=drivesdk">https://drive.google.com/file/d/1budK0m1C3Z4wkbC-DM4NmCxjhaXFBcn2/view?usp=drivesdk</a> |
| Public note |
Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Clasificación local |
| Koha item type |
Documentos solicitados |
