The methylation status of cytosines in a t gene promoter region alters with age to downregulate transcriptional activity in human cerebral cortex (Record no. 48005)
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| 000 -LEADER | |
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| fixed length control field | 01812nam a2200277Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625153929.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-13808 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | The methylation status of cytosines in a t gene promoter region alters with age to downregulate transcriptional activity in human cerebral cortex |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | NeuroScience Letters, 275, p.89-92, 1999 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | Changes with age in the methylation status of cytosines in a promoter region of the t gene were investigated in autopsy human cerebral cortex, using the bisul®te method, polymerase chain reaction (PCR)and direct sequencing of PCR products. While the total number of methylcytosines decreased with age, the changes in methylation status differed among transcription factor binding sites. Cytosines in the AP2-binding sites were never methylated in any of the cases studied at any age. Methylcytosines in the binding sites for Sp1, a transcriptional activator, signi®cantly increased with age, whereas those in the binding sites for GCF, a repressor of GC-rich promoters, signi®cantly decreased with age. These ®ndings suggest that the methylation status of cytosines in the promoter region of the t gene alters with age to decrease its transcriptional activity in the human cerebral cortex. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | PROMOTER |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | DNA METHYLATION |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | NEUROFIBRILLARY TANGLE |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | AGING |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Tohgi, H. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Utsugisawa, K. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nagane, Y. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Yoshimura, M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ukitsu, M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Genda, Y. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/1fROxHonQIhN1TS6rR1c1Xj7nIUb8Ob-u/view?usp=drivesdk">https://drive.google.com/file/d/1fROxHonQIhN1TS6rR1c1Xj7nIUb8Ob-u/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-13808 | 25.06.2025 | 25.06.2025 | Documentos solicitados |