Anti-T. cruzi Agents: Our Experience in the Evaluation of More than Five Hundred Compounds (Record no. 48058)
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| fixed length control field | 01898nam a2200181Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625153930.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-13861 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | Anti-T. cruzi Agents: Our Experience in the Evaluation of More than Five Hundred Compounds |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | Mini-Reviews in Medicinal Chemistry, 8(13), p.1355-1383, 2008 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | Chagas' disease is the major endemic disease in South and Central America caused by a trypanosomatid parasite (Trypanosoma cruzi). The current treatment relies on two old and non-specific chemotherapeutic agents, Nifurtimox and Benznidazole. Despite the major advances that have been made in the identification of specific targets that afford selectivity, the drugs used today have serious side effects. Furthermore, differences in drug susceptibility among different T. cruzi isolates have led to varied parasitological cure rates depending on the geographical region. There is, therefore, an urgent need for the development of new antichagasic drugs. In this regard we have spent more than a decade in the search for more effective agents able to compromise the proliferation of T. cruzi. We began our research with our own compounds and then continued with compounds from other researcher groups. We systematically characterized representatives of a wide range of different chemical families. In this review we summarize our ongoing efforts to identify potential anti-T. cruzi agents using our compound-library. It is discussed and presented the structure-activity relationship observed among the different groups of chemical families. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Cerecetto, H. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | González, M. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/11ab6JKQy0UtmUt6V1ypWfuAMrABsgLqd/view?usp=drivesdk">https://drive.google.com/file/d/11ab6JKQy0UtmUt6V1ypWfuAMrABsgLqd/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
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| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-13861 | 25.06.2025 | 25.06.2025 | Documentos solicitados |