Characterization of the degradation mechanisms of lysine-derived aliphatic poly (ester urethane)scaffolds (Record no. 48112)
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| fixed length control field | 02920nam a2200313Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625153931.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-13915 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | Characterization of the degradation mechanisms of lysine-derived aliphatic poly (ester urethane)scaffolds |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | BioMaterials, 32, p.419--29, 2011 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | Characterization of the degradation mechanism of polymeric scaffolds and delivery systems for regenerative medicine is essential to assess their clinical applicability. Key performance criteria include induction of a minimal, transient inflammatory response and controlled degradation to soluble noncytotoxic breakdown products that are cleared from the body by physiological processes. Scaffolds fabricated from biodegradable poly(ester urethane)s (PEURs)undergo controlled degradation to noncytotoxic breakdown products and support the ingrowth of new tissue in preclinical models of tissue regeneration. While previous studies have shown that PEUR scaffolds prepared from ysine-derived polyisocyanates degrade faster under in vivo compared to in vitro conditions, the degradation mechanism is not well understood. In this study, we have shown that PEUR scaffolds prepared from lysine triisocyanate (LTI)or a trimer of hexamethylene diisocyanate (HDIt)undergo hydrolytic, esterolytic, and oxidative degradation. Hydrolysis of ester bonds to yield a-hydroxy acids is the dominant mechanism in buffer, and esterolytic media modestly increase the degradation rate. While HDIt scaffolds show a modest (<20 percent)increase in degradation rate in oxidative medium, LTI scaffolds degrade six times faster in oxidative medium. Furthermore, the in vitro rate of degradation of LTI scaffolds in oxidative medium approximates the in vivo rate in rat excisional wounds, and histological sections show macrophages expressing myeloperoxidase at the material surface. While recent preclinical studies have underscored the potential of injectable PEUR scaffolds and delivery systems for tissue regeneration, this promising class of biomaterials has a limited regulatory history. Elucidation of the macrophage-mediated oxidative mechanism by which LTI scaffolds degrade in vivo provides key insights into the ultimate fate of these materials when injected into the body. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | POLYURETHANE |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | BIODEGRADATION |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | MACROPHAGE |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | OXIDATION |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | HYDROLYSIS |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | SCAFFOLD |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hafeman, A.E. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Katarzyna, J.Z. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Zachman, A.L. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hak-Joon, S. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nanney, L.B. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Davidson, J.M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Guelcher, S.A. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/165ussLROzZGI1JuM31wBO0FeZbHkV0es/view?usp=drivesdk">https://drive.google.com/file/d/165ussLROzZGI1JuM31wBO0FeZbHkV0es/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
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| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-13915 | 25.06.2025 | 25.06.2025 | Documentos solicitados |