Regulation of secondary metabolism in higher plants. Effect of alkaloids on a cytochrome p-450 dependent monooxygenase (Record no. 48294)
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| fixed length control field | 01656nam a2200193Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625153935.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-14099 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | Regulation of secondary metabolism in higher plants. Effect of alkaloids on a cytochrome p-450 dependent monooxygenase |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | BioChemical and Biophysical Research Communications, 66(4), p.1263-1269, 1975 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | An end-product indole alkaloid, catharanthine, inhibits a membranebound cytochrome P-450 dependent monooxygenase of the higher plant, Vinca rosea. Kinetic analysis revealed the alkaloid to be a reversible, linear, non-competitive inhibitor (Ki=l mM)with resp.ect to its substrates, geraniol and NADPH. Comparable inhibition of the solubilised monooxygenase by catharanthine tends to exclude a mechanism based upon disruption of membrane organization. On the basis of its inhibition of solubilized hydroxylase in the presence and absence of sodium cholate, it is also unlikely that catharanthine competes for putative phospholipid binding site(s). Two additional end-product alkaloids, vinblastine and vindoline were less inhibitory. Since the hydroxylase catalyzes one of the first committed steps in the biosynthesis of indole alkaloids, these observations suggest feedback control of the pathway by catharanthine. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mcfarlane, J. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Madyastha, K.M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Coscia, Carmine J. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/11j0wYoULi8T-beBcK8hiouWCf9GZyXxI/view?usp=drivesdk">https://drive.google.com/file/d/11j0wYoULi8T-beBcK8hiouWCf9GZyXxI/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
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| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-14099 | 25.06.2025 | 25.06.2025 | Documentos solicitados |