Xanthones with neuraminidase inhibitory activity from the seedcases of Garcinia mangostana (Record no. 48329)
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| fixed length control field | 01932nam a2200241Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625153935.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-14134 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | Xanthones with neuraminidase inhibitory activity from the seedcases of Garcinia mangostana |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | Bioorganic & medicinal Chemistry, 18(17), p.6258-6264, 2010 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | This study was designed to gain deeper insights into the molecular properties of natural xanthones as neuraminidase inhibitors. A series of xanthones 1-12 was isolated from the seedcases of Garcinia mangostana and evaluated for bacteria neuraminidase inhibitory activity. Compounds 11 and 12 emerged to be new xanthones (mangostenone F, mangostenone G)which we fully spectroscopically characterized. The IC(50)values of compounds 1-12 were determined to range between 0.27-65.7 microM. The most potent neuraminidase inhibitor 10 which has an IC(50)of 270 nM features a 5,8-diol moiety on the B ring. Interestingly, structure-activity studies reveal that these xanthones show different kinetic inhibition mechanisms depending upon the arrangement of hydroxyl groups in the B ring. Compound 6 possessing a 6,7-diol motif on the B-ring operated under the enzyme isomerization model (k(5)=0.1144 microM(-1)s(-1), k(6)=0.001105 s(-1), and K(i)(app)=7.41 microM), whereas compound 10 possessing a 5,8-diol unit displayed simple reversible slow-binding inhibition (k(3)=0.02294 microM(-1)s(-1), k(4)=0.001025 s(-1), and K(i)(app)=0.04468 microM). |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ryu, H. W. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Curtis-Long, M. J. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Jung, S. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Jin, Y. M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Cho, J. K. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ryu, Y. B. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Park, K. H |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/1lubyBvrFeQMv_fU5apI-rEwi5ypDSG6g/view?usp=drivesdk">https://drive.google.com/file/d/1lubyBvrFeQMv_fU5apI-rEwi5ypDSG6g/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-14134 | 25.06.2025 | 25.06.2025 | Documentos solicitados |