Flavonoids Influence Monocytic GTPase Activity and Are Protective in Experimental Allergic Encephalitis (Record no. 48347)

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control field 20250625153936.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-14153
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245 10 - TITLE STATEMENT
Title Flavonoids Influence Monocytic GTPase Activity and Are Protective in Experimental Allergic Encephalitis
490 0# - SERIES STATEMENT
Volume/sequential designation The Journal of Experimental Medicine, 200(12), p.1667-1672, 2004
520 3# - SUMMARY, ETC.
Summary, etc. In the chronic disabling disease multiple sclerosis (MS), migration of monocytes across the blood-brain barrier is a crucial step in the formation of new lesions in the central nervous system (CNS). Infiltrating monocyte-derived macrophages secrete inflammatory mediators such as oxygen radicals, which contribute to axonal demyelination and damage, resulting in neurological deficits. Flavonoids are compounds occurring naturally in food, which scavenge oxygen radicals and have antiinflammatory properties. To investigate whether they might suppress clinical symptoms in MS, we treated rats sensitized for acute and chronic experimental allergic encephalomyelitis, an experimental model of MS, with flavonoids. We demonstrated that the flavonoid luteolin substantially suppressed clinical symptoms and prevented relapse when administered either before or after disease onset. Luteolin treatment resulted in reduced inflammation and axonal damage in the CNS by preventing monocyte migration across the brain endothelium. Luteolin influenced migration by modulating the activity of Rho GTPases, signal transducers involved in transendothelial migration. Oral administration of luteolin also significantly reduced clinical symptoms.
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element MULTIPLE SCLEROSIS
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Topical term or geographic name entry element LUTEOLIN
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element BLOOD-BRAIN BARRIER
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element MACROPHAGE
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element RHOA
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Hendriks, J.J.A.
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Personal name Alblas, J.
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Personal name Van Der Pol, S.M.A.
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Personal name Van Tol, E.A.F.
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Personal name Dijkstra, C.D.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name De Vries, H.E.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/10MibzidGn9pQY2JqeEeeJbyaAxbzphd1/view?usp=drivesdk">https://drive.google.com/file/d/10MibzidGn9pQY2JqeEeeJbyaAxbzphd1/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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Source of classification or shelving scheme Clasificación local
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-14153 25.06.2025 25.06.2025 Documentos solicitados