Absorption, transport, and disposition of ascorbic acid in humans (Record no. 48369)

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control field MX-MdCICY
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control field 20250625153936.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-14175
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Title Absorption, transport, and disposition of ascorbic acid in humans
490 0# - SERIES STATEMENT
Volume/sequential designation The Journal Nutritional BioChemistry, 9(9), p.116-130, 1998
520 3# - SUMMARY, ETC.
Summary, etc. L-ascorbic acid (ascorbate or vitamin C)is a required nutrient for humans. Absorption, transport, and disposition of ingested ascorbate involve the following: (1)bioavailability and absorption in the gastrointestinal tract; (2)presence in the circulation; (3)tissue distribution; (4)excretion; and, (5)metabolism. Fundamental to each of the above are ascorbate chemistry and mechanisms of transport of ascorbate across membranes. Ascorbate can be reversibly oxidized to dehydroascorbic acid, which can be irreversibly degraded. Both reduced and oxidized forms cross cell membranes. Differences in transport kinetics, tissue specificity, and Na1 and energy dependence strongly support the existence of separate transport mechanisms. An important consideration in the analysis of ascorbate transport is that of substrate availability. Reduced ascorbate is by far the most predominant form found in plasma and tissues. Dehydroascorbic acid is rapidly reduced intracellularly to ascorbate by both enzymatic and chemical mechanisms. Despite constitutively low levels of dehydroascorbic acid, conditions that promote oxidation of ascorbate can profoundly alter both the nature and availability of substrate. Elucidation of mechanisms that modulate the delivery of ascorbate to tissues and its utilization under different metabolic conditions will be invaluable for making recommendations for ascorbate ingestion.
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element ASCORBIC ACID
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element VITAMIN C
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element DEHYDROASCORBIC ACID
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element TRANSPORT
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element PHARMACOKINETICS
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element ASCORBATE RECYCLING
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Rumsey, S.C.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Levine, M.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/10jhYMEoQLgjuDpoiAoRCPYP4ShakhIv4/view?usp=drivesdk">https://drive.google.com/file/d/10jhYMEoQLgjuDpoiAoRCPYP4ShakhIv4/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-14175 25.06.2025 25.06.2025 Documentos solicitados