Functional properties of a recombinant bacterial DING protein: Comparison with a homologous human protein (Record no. 48547)

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control field MX-MdCICY
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250625153940.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-14354
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245 10 - TITLE STATEMENT
Title Functional properties of a recombinant bacterial DING protein: Comparison with a homologous human protein
490 0# - SERIES STATEMENT
Volume/sequential designation Biochimica et Biophysica Acta, 1744(2), p.234-244, 2005
520 3# - SUMMARY, ETC.
Summary, etc. DING proteins are highly-conserved proteins with poorly-defined cell-signalling roles in mammals. Conserved homologues are also commonplace in plants, though not as yet functionally characterized. Poor availability of the proteins, and a lack of genetic structure, hamper progress in elucidating the roles of these eukaryotic DING proteins, but highly-homologous hypothetical DING proteins have recently been identified in Pseudomonas genomes. We have cloned and expressed a DING protein from P. fluorescens SWB25 in Escherichia coli. The recombinant protein, and its natural human homologue, act as phosphate-binding proteins, as predicted by structural homologies with other bacterial proteins. The recombinant protein also displays other functional similarities with mammalian DING proteins, in that, like the human version, it acts as a mitogen for cultured human cells, and can bind cotinine, known to be a binding ligand for a rat neuronal DING protein.
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element DING PROTEIN
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element CELL-SIGNALING
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element PSEUDOMONAS FLUORESCENS
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element HUMAN
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element MITOGEN
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element PHOSPHATE-BINDING
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Scott, K.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Wu, L.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1gHdYM5Dhp1_BbqrEsfuAURoIIWTJd4xr/view?usp=drivesdk">https://drive.google.com/file/d/1gHdYM5Dhp1_BbqrEsfuAURoIIWTJd4xr/view?usp=drivesdk</a>
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Source of classification or shelving scheme Clasificación local
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-14354 25.06.2025 25.06.2025 Documentos solicitados