Strategies for Engineering Plant Natural Products: The Iridoid-Derived Monoterpene Indole Alkaloids of Catharanthus roseus (Record no. 48562)

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control field MX-MdCICY
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control field 20250625153940.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-14370
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Title Strategies for Engineering Plant Natural Products: The Iridoid-Derived Monoterpene Indole Alkaloids of Catharanthus roseus
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Volume/sequential designation Methods in Enzymology, 515, p.189-206, 2012
520 3# - SUMMARY, ETC.
Summary, etc. The manipulation of pathways to make unnatural variants of natural compounds, a process often termed combinatorial biosynthesis, has been robustly successful in prokaryotic systems. The development of approaches to generate new-to-nature compounds from plant-based pathways is, in comparison, much less advanced. Success will depend on the specific chemistry of the pathway, as well as on the suitability of the plant system for transformation and genetic manipulation. As plant pathways are elucidated, and can be heterologously expressed in hosts that are more amenable to genetic manipulation, biosynthetic production of new-to-nature compounds from lant pathways will become more widespread. In this chapter, some of the key strategies that have been developed for metabolic engineering of plant pathways, namely directed biosynthesis, mutasynthesis, and pathway incorporation of engineered enzymes are highlighted. The iridoid-derived monoterpene indole alkaloids from C. roseus, which are the focus of this chapter, provide an excellent system for developing these strategies.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name O'Connor, S.E.
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Uniform Resource Identifier <a href="https://drive.google.com/file/d/13_-CtwuhQ8LcdZPVySmS3mnqcNeQ_DKu/view?usp=drivesdk">https://drive.google.com/file/d/13_-CtwuhQ8LcdZPVySmS3mnqcNeQ_DKu/view?usp=drivesdk</a>
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-14370 25.06.2025 25.06.2025 Documentos solicitados