Gentamicin bone cements: characterisation and release (in vitro and in vivo assays) (Record no. 48590)

MARC details
000 -LEADER
fixed length control field 02192nam a2200253Ia 4500
003 - CONTROL NUMBER IDENTIFIER
control field MX-MdCICY
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250625153940.0
040 ## - CATALOGING SOURCE
Transcribing agency CICY
090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN)
Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-14400
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 250602s9999 xx |||||s2 |||| ||und|d
245 10 - TITLE STATEMENT
Title Gentamicin bone cements: characterisation and release (in vitro and in vivo assays)
490 0# - SERIES STATEMENT
Volume/sequential designation International Journal of Pharmaceutics, 217(1-2), p.57-69, 2001
520 3# - SUMMARY, ETC.
Summary, etc. Due to the extended use of acrylic bone cements, its necessary to develop improved formulations in order to resolve their many drawbacks. The present work was conducted to make a physical-chemical characterisation of this kind of acrylic cement in order to introduce future changes in the formulations to: (1)improve or at least maintain their mechanical properties; (2)diminish their toxicity, and (3)control the drug release (rate and amount). From the dissolution method we can conclude that the preparation method (with or without pressure)of specimens is not responsible for the erratic release. The cumulative amount of gentamicin released was fitted to a semi-empirical equation to explain the possible release mechanism. The powder size, shape and distribution that could affect several properties of bone cement were studied with the aid of different techniques such as SEM, laser diffraction spectroscopy, and powder X-ray diffraction. From SEM micrographs, it was possible to observe that the surfaces of the specimens were very irregular with numerous small craters that may serve as conduits for eluting the antibiotic. An 'in vitro' drug diffusion model is proposed to elucidate the drug release mechanism. Finally an 'in vivo' study was performed to evaluate the antibiotic release to the neighbouring bone sites.
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element PMMA BONE CEMENTS
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element GENTAMICIN
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element IN VITRO' RELEASE
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element PHYSICAL-CHEMICAL CHARACTERISATION
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element IN VITRO' DRUG DIFFUSION
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Torrado, S.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Frutos, P.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Frutos, G.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1vSQSKvBoN6j4lqTODbtqtcM727-qXKP6/view?usp=drivesdk">https://drive.google.com/file/d/1vSQSKvBoN6j4lqTODbtqtcM727-qXKP6/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme Clasificación local
Koha item type Documentos solicitados
Holdings
Lost status Source of classification or shelving scheme Damaged status Not for loan Collection Home library Current library Shelving location Date acquired Total checkouts Full call number Date last seen Price effective from Koha item type
  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-14400 25.06.2025 25.06.2025 Documentos solicitados