Air pollution interacts with genetic risk to influence cortical networks implicated in depression (Record no. 48643)
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| 000 -LEADER | |
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| fixed length control field | 02455nam a2200301Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625153941.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-14455 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | Air pollution interacts with genetic risk to influence cortical networks implicated in depression |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | Proceedings of the National Academy of Sciences, 118(46), p.e2109310118, 2021 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | Air pollution is a reversible cause of significant global mortality and morbidity. Epidemiological evidence suggests associations between air pollution exposure and impaired cognition and increased risk for major depressive disorders. However, the neural bases of these associations have been unclear. Here, in healthy human subjects exposed to relatively high air pollution and controlling for socioeconomic, genomic, and other confounders, we examine across multiple levels of brain network function the extent to which particulate matter (PM2.5)exposure influences putative genetic risk mechanisms associated with depression. Increased ambient PM2.5 exposure was associated with poorer reasoning and problem solving and higher-trait anxiety/depression. Working memory and stress-related information transfer (effective connectivity)across cortical and subcortical brain networks were influenced by PM2.5 exposure to differing extents depending on the polygenic risk for depression in gene-by-environment interactions. Effective connectivity patterns from individuals with higher polygenic risk for depression and higher exposures with PM2.5, but not from those with lower genetic risk or lower exposures, correlated spatially with the coexpression of depression-associated genes across corresponding brain regions in the Allen Brain Atlas. These converging data suggest that PM2.5 exposure affects brain network functions implicated in the genetic mechanisms of depression.. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | MAJOR DEPRESSIVE DISORDER |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | POLYGENIC RISK |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | FINE PARTICULATE MATTER |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | PM2.5 |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | GENE-ENVIRONMENT INTERACTION |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Li, Z. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Yan, H. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Zhang, X. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Shah, S. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Yang, G. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Chen, Q. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Tan, H. Y. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/17crlPcrO-WgIuuUmWTgV6JsDRkA1IdZz/view?usp=drivesdk">https://drive.google.com/file/d/17crlPcrO-WgIuuUmWTgV6JsDRkA1IdZz/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
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| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-14455 | 25.06.2025 | 25.06.2025 | Documentos solicitados |