MARC details
| 000 -LEADER |
|---|
| fixed length control field |
02511nam a2200265Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
|---|
| control field |
20250625153944.0 |
| 040 ## - CATALOGING SOURCE |
|---|
| Transcribing agency |
CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
|---|
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
B-14596 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Differential inhibition of human cytochrome P450 enzymes by "-viniferin, the dimer of resveratrol: comparison with resveratrol and polyphenols from alcoholized beverages |
| 490 0# - SERIES STATEMENT |
|---|
| Volume/sequential designation |
Life Sciences, 73(9), p.1199-1213, 2003 |
| 520 3# - SUMMARY, ETC. |
|---|
| Summary, etc. |
E-Viniferin, a dimer of resveratrol, was isolated in wine at concentration between 0.5 and 5 AM. As resveratrol and polyphenols from red wine were reported to inhibit cytochrome P450 (CYP)activities, this led us to investigate the inhibitory effects of "-viniferin on human CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2B6, CYP2E1, CYP3A4 and CYP4A activities. These effects were compared to those of resveratrol and non volatiles compounds from red wine or various CognacR beverages (enriched with oak-polyphenols). Assays were carried out on human liver microsomes and heterologously expressed CYPs. Ethoxyresorufin, coumarin, benzoxyresorufin, chlorzoxazone, testosterone and lauric acid were used as selective substrates for CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2B6, CYP2E1, CYP3A4 and CYP4A, respectively. "-viniferin displayed a more potent inhibitory effect than resveratrol for all the CYP activities tested (Ki 0.5 to 20 AM vs. 10 to 100 AM, respectively). This effect was not due to an inhibition of the NADPH reductase. A particularly potent inhibitory effect was shown for CYP1A1, CYP1B1 and CYP2B6 which are involved in bioactivation of numerous carcinogens. "-viniferin was not a mechanism-based inhibitor of human CYPs. It displayed, like resveratrol, mixed-type inhibitions for all the CYP tested, except for CYP2E1 (non-competitive). Comparison of the inhibitory effects exerted on CYP activities by "-viniferin , resveratrol and non volatile components from red wine or various Cognac beverages showed that neither resveratrol, nor "-viniferin is the main CYP inhibitor present in red wine solids. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
CYTOCHROME P450 INHIBITION |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
CYP |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
E-VINIFERIN |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
RESVERATROL |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
RED WINE |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Piver, B. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Berthou, F. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Dreano, Y. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Lucas, D. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Uniform Resource Identifier |
<a href="https://drive.google.com/file/d/1kMDLDPnCWuEXqfkxQM0N5FtKtYCz5ZpQ/view?usp=drivesdk">https://drive.google.com/file/d/1kMDLDPnCWuEXqfkxQM0N5FtKtYCz5ZpQ/view?usp=drivesdk</a> |
| Public note |
Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Clasificación local |
| Koha item type |
Documentos solicitados |
