Synthesis and biological evaluation of cytotoxic properties of stilbene-based resveratrol analogs (Record no. 48786)

MARC details
000 -LEADER
fixed length control field 01902nam a2200313Ia 4500
003 - CONTROL NUMBER IDENTIFIER
control field MX-MdCICY
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250625153944.0
040 ## - CATALOGING SOURCE
Transcribing agency CICY
090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN)
Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-14600
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 250602s9999 xx |||||s2 |||| ||und|d
245 10 - TITLE STATEMENT
Title Synthesis and biological evaluation of cytotoxic properties of stilbene-based resveratrol analogs
490 0# - SERIES STATEMENT
Volume/sequential designation European Journal of Medicinal Chemistry, 44(2), p.701-707, 2009
520 3# - SUMMARY, ETC.
Summary, etc. This work deals with the preparation of stilbene-based resveratrol analogs by employing the Perkin reaction, aiming at synthesizing potential antitumor lead compounds and evaluating their pharmacological activities. The proliferation inhibitor test against tumor cell lines identified analogs 9 and 11 as the most active among all synthesized derivatives, presenting IC50 in micromolar range for certain cell lines. For study on the embryonic development, compounds 8 and 9 at the lowest tested concentration (41.7 mM)that inhibited sea urchin egg development, but only after third cleavage were used. Both the compounds inhibited 100 percent of normal development since first cleavage. These data partially corroborated the results obtained with MTT assay using tumor cell lines. None of the tested compounds revealed hemolytic action in assay with mouse erythrocytes.
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element STILBENES
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element RESVERATROL ANALOGS
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element CYTOTOXIC PROPERTIES
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element EMBRYONIC DEVELOPMENT
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Rotta, R.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Marques, M.R.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Montenegro, R.C.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Vasconcellos, M.C.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Pessoa, C.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name De Moraes M.O.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Costa-Lotufo L.V.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Costa-Lotufo L.V.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Nogueira Eberlin, M.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1M6iGesr7a6IDfzgOsYf5g7ALjH9tNAYF/view?usp=drivesdk">https://drive.google.com/file/d/1M6iGesr7a6IDfzgOsYf5g7ALjH9tNAYF/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme Clasificación local
Koha item type Documentos solicitados
Holdings
Lost status Source of classification or shelving scheme Damaged status Not for loan Collection Home library Current library Shelving location Date acquired Total checkouts Full call number Date last seen Price effective from Koha item type
  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-14600 25.06.2025 25.06.2025 Documentos solicitados