Triacylglycerol Synthesis Enzymes Mediate Lipid Droplet Growth by Relocalizing from the ER to Lipid Droplets (Record no. 48937)

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fixed length control field 02060nam a2200349Ia 4500
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control field MX-MdCICY
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control field 20250625153947.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-14752
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Title Triacylglycerol Synthesis Enzymes Mediate Lipid Droplet Growth by Relocalizing from the ER to Lipid Droplets
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Volume/sequential designation Developmental Cell, 24, p.384-399, 2013
520 3# - SUMMARY, ETC.
Summary, etc. Lipid droplets (LDs)store metabolic energy and membrane lipid precursors. With excess metabolic energy, cells synthesize triacylglycerol (TG)and form LDs that grow dramatically. It is unclear how TG synthesis relates to LD formation and growth. Here, we identify two LD subpopulations: smaller LDs of relatively constant size, and LDs that grow larger. The latter population contains isoenzymes for each step of TG synthesis. Glycerol-3-phosphate acyltransferase 4 (GPAT4), which catalyzes the first and rate-limiting step, relocalizes from the endo-plasmic reticulum (ER)to a subset of forming LDs, where it becomes stably associated. ER-to-LD tar-getingof GPAT4 andother LD-localizedTGsynthesis isozymes is required for LD growth. Key features of GPAT4 ER-to-LD targeting and function in LDgrowth are conserved betweenDrosophilaand mammalian cells. Our results explain how TG synthesis is coupled with LD growth and identify two distinct LD subpopulations based on their capacity for local-ized TG synthesis.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Wilfling, F.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Wang, H.
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Personal name Haas, J.T.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Krahmer, N.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Gould, T.J.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Uchida, A.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Cheng, J-X.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Cheng, J-X.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Christiano, R.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Fröhlich, F.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Liu, X.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Buhman, K.K.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Coleman, R.A.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Bewersdorf, J.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Farese, R.V.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Walther, T.C.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/10bgS08WQFNM5qQL1PKnpCN37U8AwMa6z/view?usp=drivesdk">https://drive.google.com/file/d/10bgS08WQFNM5qQL1PKnpCN37U8AwMa6z/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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Source of classification or shelving scheme Clasificación local
Koha item type Documentos solicitados
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-14752 25.06.2025 25.06.2025 Documentos solicitados