The Influence of Hydroxyapatite Particles onIn Vitro Degradation Behavior of Polye-Caprolactone-Based Composite Scaffolds (Record no. 49028)

MARC details
000 -LEADER
fixed length control field 02525nam a2200229Ia 4500
003 - CONTROL NUMBER IDENTIFIER
control field MX-MdCICY
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250625153949.0
040 ## - CATALOGING SOURCE
Transcribing agency CICY
090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN)
Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-14843
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 250602s9999 xx |||||s2 |||| ||und|d
245 10 - TITLE STATEMENT
Title The Influence of Hydroxyapatite Particles onIn Vitro Degradation Behavior of Polye-Caprolactone-Based Composite Scaffolds
490 0# - SERIES STATEMENT
Volume/sequential designation Tissue Engineering: Part A, 15(11), p.3655-3668, 2009
520 3# - SUMMARY, ETC.
Summary, etc. The design of composite scaffolds with slow degradation kinetics imposes the assessment of the time-course of degradation to predict the long-termin vitro behavior. In this work, the effect of hydroxyapatite (HA)particles on the hydrolytic degradation of polye-caprolactone composite scaffold was investigated. The study of accel-erated degradation mechanisms in alkaline medium enabled analysing comparable degradation profiles at different times. The accurate qualitative and quantitative study of morphology by scanning electron microscopy supported by image analysis demonstrated only a negligible effect on the structural porosity, to be ascribed to the addition of micrometric HA as a filler. Moreover, by comparing the Raman spectra with thermal analysis (thermogravimetry and differential scanning calorimetry)the role of HA on the composite degradation mech-anism was defined, by separately quantifying the contribution of HA particles in the bulk and on the surface, on the bone formation as a function of modifications induced in the pore morphology, as well as physical and chemical properties of the polymer matrix. Indeed, HA particles alter the poly e-caprolactone crystallinity inducing a ''shielding'' effect of the polymer matrix. Meanwhile, the slight reduction of pore size as a function of the increasing HA content and the improvement of the effective hydrophilicity of the scaffolds also influence the degradation by faster mechanisms. Finally, it has been proven that the presence of HA enhances the scaffold bioactivity and human osteoblast cell response, remarking the active role of bioactive signals on the promotion of the surface mineralization and, as a consequence, on the cell-material interaction.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Guarino, V.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Taddei, P.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Di Foggia, M.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Fagnano, C.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Ciapetti, G.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Ambrosio, L.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1D3MPedzA5UVNEjJ3g0UWlzNVj8YyP9Vx/view?usp=drivesdk">https://drive.google.com/file/d/1D3MPedzA5UVNEjJ3g0UWlzNVj8YyP9Vx/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme Clasificación local
Koha item type Documentos solicitados
Holdings
Lost status Source of classification or shelving scheme Damaged status Not for loan Collection Home library Current library Shelving location Date acquired Total checkouts Full call number Date last seen Price effective from Koha item type
  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-14843 25.06.2025 25.06.2025 Documentos solicitados