Salt selection for basic drugs (Record no. 49135)

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Transcribing agency CICY
090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN)
Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-14951
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245 10 - TITLE STATEMENT
Title Salt selection for basic drugs
490 0# - SERIES STATEMENT
Volume/sequential designation International Journal of Pharmaceutics, 33(1-3), p.201-217, 1986
520 3# - SUMMARY, ETC.
Summary, etc. An attempt has been made using a Kepner-Tregoe decision analysis approach to provide rationale to salt selection for basic drugs. The selection objectives are reviewed in terms of the 'essential' (MUSTS)and 'desirable' (WANTS)issues. The desired characteristics of the salt form, given sufficient strength and toxicological suitability of the conjugate acid, are then discussed on the basis of the various pivotal physicochemical properties; melting point, aqueous solubility and dissolution rate, stability and hydrophobicity. Several trends are established which can then assist the decision of which range of salt forms to evaluate to overcome a particular problem with a basic drug. It is concluded that it is important to view the choice of salt form for development as a compromise, with particular focus on the correctly weighted desires to obtain the best balanced choice.
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element SALT FORM SELECTION
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element PHARMACEUTICAL SALTS
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Gould, P.L.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1H3o0dNJTu2J6CBl7_FN8XtA4W396SL0d/view?usp=drivesdk">https://drive.google.com/file/d/1H3o0dNJTu2J6CBl7_FN8XtA4W396SL0d/view?usp=drivesdk</a>
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