In vitro anti-influenza activity of a protein-enriched fraction from larvae of the housefly (Musca domestica) (Record no. 49372)

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fixed length control field 02366nam a2200229Ia 4500
003 - CONTROL NUMBER IDENTIFIER
control field MX-MdCICY
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250625153955.0
040 ## - CATALOGING SOURCE
Transcribing agency CICY
090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN)
Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-15191
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245 10 - TITLE STATEMENT
Title In vitro anti-influenza activity of a protein-enriched fraction from larvae of the housefly (Musca domestica)
490 0# - SERIES STATEMENT
Volume/sequential designation Pharmaceutical Biology, 51(3), p.405-410, 2013
520 3# - SUMMARY, ETC.
Summary, etc. Context: Insects are a large, unexplored and unexploited source of potentially useful compounds for modern medicine. The larvae of the housefly (Musca domestica)have been used to study immune-induced molecules because they can survive in pathogenic environments. Objective: The antiviral activity of a protein-enriched fraction (PEF)from the larvae of the housefly was evaluated in vitro and the possible antiviral mechanism was studied. Materials and methods: PEF was isolated from the larvae of the housefly. The cytotoxicity of PEF was detected by the MTT assay. The in vitro antiviral activity of PEF against influenza virus was investigated. PEF was incubated with the virus and its target cells under various conditions, and its antiviral effects were examined by reduction in virus yield in cell cultures. Experiments with ribavirin were performed in parallel under the same conditions. Results: The results indicated that PEF had minimal cytotoxicity against MDCK cells and the CC value was calculated to be 284.45 µg/ml. The antiviral results showed the loss of infectious capacity was more than two log (2)units in cell cultures compared with virus control. The effect of PEF was direct virucidal activity and the interference on the adsorption of cell and virus. The antiviral mechanism of PEF is different from ribavirin. Conclusion: The results indicate that PEF showed strong antiviral activity against influenza virus at a very early stage of the interaction with virus particles or their entry into the cells. PEF has a great potential as a resource of healthy products.
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element ANTIVIRAL ACTIVITY
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element HEMAGGLUTININ TITER
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element INFLUENZA VIRUS
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Wang, F.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Ai, H.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Lei, C.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1Q99AKWmviYslUWLhojGMltAolOyAS6fT/view?usp=drivesdk">https://drive.google.com/file/d/1Q99AKWmviYslUWLhojGMltAolOyAS6fT/view?usp=drivesdk</a>
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Source of classification or shelving scheme Clasificación local
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-15191 25.06.2025 25.06.2025 Documentos solicitados