Evolution and classification of the CRISPR-Cas systems (Record no. 50119)

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control field MX-MdCICY
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control field 20250625160142.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-15943
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Title Evolution and classification of the CRISPR-Cas systems
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Volume/sequential designation Nature Reviews MicroBiology, 9(6), p.467-477, 2011
520 3# - SUMMARY, ETC.
Summary, etc. The CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR-associated proteins)modules are adaptive immunity systems that are present in many archaea and bacteria. These defence systems are encoded by operons that have an extraordinarily diverse architecture and a high rate of evolution for both the cas genes and the unique spacer content. Here, we provide an updated analysis of the evolutionary relationships between CRISPR-Cas systems and Cas proteins. Three major types of CRISPR-Cas system are delineated, with a further division into several subtypes and a few chimeric variants. Given the complexity of the genomic architectures and the extremely dynamic evolution of the CRISPR-Cas systems, a unified classification of these systems should be based on multiple criteria. Accordingly, we propose a 'polythetic' classification that integrates the phylogenies of the most common cas genes, the sequence and organization of the CRISPR repeats and the architecture of the CRISPR-cas loci. © 2011 Macmillan Publishers Limited. All rights reserved.
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Topical term or geographic name entry element CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN
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Topical term or geographic name entry element CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS CRISPR ASSOCIATED PROTEIN
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Topical term or geographic name entry element UNCLASSIFIED DRUG
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Personal name Makarova, K.S.
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Personal name Haft, D.H.
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Personal name Barrangou, R.
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Personal name Brouns, S.J.J.
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Personal name Charpentier, E.
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Personal name Horvath, P.
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Personal name Moineau, S.
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Personal name Moineau, S.
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Personal name Wolf, Y.I.
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Personal name Yakunin, A.F.
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Personal name Van Der Oost, J.
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Personal name Koonin, E.V.
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Uniform Resource Identifier <a href="https://drive.google.com/file/d/1QoGtdaC5srpNJhE8zJi4PJ1SvwGDM7Sl/view?usp=drivesdk">https://drive.google.com/file/d/1QoGtdaC5srpNJhE8zJi4PJ1SvwGDM7Sl/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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Source of classification or shelving scheme Clasificación local
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-15943 25.06.2025 25.06.2025 Documentos solicitados