Combating multidrug-resistant Gram-negative bacteria with structurally nanoengineered antimicrobial peptide polymers (Record no. 50429)
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| fixed length control field | 02457nam a2200313Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625160148.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-16255 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | Combating multidrug-resistant Gram-negative bacteria with structurally nanoengineered antimicrobial peptide polymers |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | Nature MicroBiology, 1(Article number 16162), 2016 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | With the recent emergence of reports on resistant Gram-negative 'superbugs', infections caused by multidrug-resistant (MDR)Gram-negative bacteria have been named as one of the most urgent global health threats due to the lack of effective and biocompatible drugs. Here, we show that a class of antimicrobial agents, termed 'structurally nanoengineered antimicrobial peptide polymers' (SNAPPs)exhibit sub-µM activity against all Gram-negative bacteria tested, including ESKAPE and colistin-resistant and MDR (CMDR)pathogens, while demonstrating low toxicity. SNAPPs are highly effective in combating CMDR Acinetobacter baumannii infections in vivo, the first example of a synthetic antimicrobial polymer with CMDR Gram-negative pathogen efficacy. Furthermore, we did not observe any resistance acquisition by A. baumannii (including the CMDR strain)to SNAPPs. Comprehensive analyses using a range of microscopy and (bio)assay techniques revealed that the antimicrobial activity of SNAPPs proceeds via a multimodal mechanism of bacterial cell death by outer membrane destabilization, unregulated ion movement across the cytoplasmic membrane and induction of the apoptotic-like death pathway, possibly accounting for why we did not observe resistance to SNAPPs in CMDR bacteria. Overall, SNAPPs show great promise as low-cost and effective antimicrobial agents and may represent a weapon in combating the growing threat of MDR Gram-negative bacteria. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | BACTERIA |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | ANTIMICROBIAL PEPTIDE POLYMERS |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lam, S.J. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | O'Brien-Simpson, N.M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Pantarat, N. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sulistio, A. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wong, E.H.H. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Chen, Y.-Y. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lenzo, J.C. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lenzo, J.C. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Blencowe, A. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Reynolds, E.C. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Qiao, G.G. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/1yvG5C_SzdnqwTwKdTGcAbx6sBDZPn4nb/view?usp=drivesdk">https://drive.google.com/file/d/1yvG5C_SzdnqwTwKdTGcAbx6sBDZPn4nb/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
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| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-16255 | 25.06.2025 | 25.06.2025 | Documentos solicitados |