Antifungal activity of ß-carbolines on Penicillium digitatum and Botrytis cinerea (Record no. 50505)

MARC details
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fixed length control field 02279nam a2200301Ia 4500
003 - CONTROL NUMBER IDENTIFIER
control field MX-MdCICY
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250625160149.0
040 ## - CATALOGING SOURCE
Transcribing agency CICY
090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN)
Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-16331
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245 10 - TITLE STATEMENT
Title Antifungal activity of ß-carbolines on Penicillium digitatum and Botrytis cinerea
490 0# - SERIES STATEMENT
Volume/sequential designation Food MicroBiology, 62, p.9-14, 2017
520 3# - SUMMARY, ETC.
Summary, etc. ß-carbolines (ßCs)are alkaloids widely distributed in nature that have demonstrated antimicrobial properties. Here, we tested in vitro six ßCs against Penicillium digitatum and Botrytis cinerea, causal agents of postharvest diseases on fruit and vegetables. Full aromatic ßCs (harmine, harmol, norharmane and harmane)exhibited a marked inhibitory effect on conidia germination at concentrations between 0.5 and 1 mM, while dihydro-ßCs (harmalina and harmalol)only caused germination delay. Harmol showed the highest inhibitory effect on both fungal pathogens. After 24 h of exposure to 1 mM harmol, conidia revealed a severe cellular damage, exhibiting disorganized cytoplasm and thickened cell wall. Harmol antimicrobial effect was fungicidal on B. cinerea, while it was fungistatic on P. digitatum. Conidia membrane permeabilization was detected in treatments with harmol at sub-inhibitory and inhibitory concentrations, for both pathogens. In addition, residual infectivity of P. digitatum on lemons and B. cinerea on blueberries was significantly reduced after exposure to this alkaloid. It also inhibited mycelial growth, preventing sporulation at the highest concentration tested. These results indicate that harmol might be a promising candidate as a new antifungal molecule to control causal agents of fruit diseases.
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element ALKALOIDS
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element CONIDIAL MEMBRANE PERMEABILIZATION
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element GERMINATION INHIBITION
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element HARMOL
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element INFECTIVITY
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element PHYTOPATHOGENS
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Olmedo, G.M.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Cerioni, L.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name González, M.M.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Cabrerizo, F.M.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Rapisarda, V.A.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Volentini, S.I.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1La_OagBdZhBK-_SZ7BsVq_AIsdA6A1ve/view?usp=drivesdk">https://drive.google.com/file/d/1La_OagBdZhBK-_SZ7BsVq_AIsdA6A1ve/view?usp=drivesdk</a>
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942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme Clasificación local
Koha item type Documentos solicitados
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Lost status Source of classification or shelving scheme Damaged status Not for loan Collection Home library Current library Shelving location Date acquired Total checkouts Full call number Date last seen Price effective from Koha item type
  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-16331 25.06.2025 25.06.2025 Documentos solicitados