MARC details
| 000 -LEADER |
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| fixed length control field |
01948nam a2200277Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20250625160150.0 |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
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| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
B-16385 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT |
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| Title |
A mitochondrial membrane hypothesis of aging |
| 490 0# - SERIES STATEMENT |
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| Volume/sequential designation |
Journal of Theoretical Biology, 127(2), p.127-132, 1987 |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
Recently it has been demonstrated that the loss of water during aging from rat liver and heart muscle tissue is solely due to water loss from the mitochondria. A hypothesis is presented here which shows the relation between free radical attack to, and water loss from, the mitochondria and the decreased energy availability in aged cells. According to it, water loss from the mitochondria is due to an increasing permeability of the inner mitochondrial membrane as a result of its changed composition and, therefore, decreasing osmotic reflexion coefficients for inorganic ions, mainly potassium. The water loss results in limited diffusion of intramitochondrial metabolites and, according to the theory of polyelectrolyte solutions, electrostatic and sterical hindrance of enzymic functions. The hypothesis is in accordance with the well-documented experimental facts, e.g. the lack of structural alterations in mitochondrial DNA and proteins, the constancy of the ?µH+ and the decrease of state 3 respiration with only a limited number of substrates in mitochondria from old postmitotic cells. © 1987 Academic Press Ltd. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
AGING |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
ANIMAL |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
ARTICLE |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
CELL MEMBRANE |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
CELL MEMBRANE PERMEABILITY |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
METABOLISM |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
MITOCHONDRION |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
PHYSIOLOGY |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
RAT |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Zglinicki, T. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="https://drive.google.com/file/d/1YXM4qQWioN3BHvuiIL9DFFapaXupqudh/view?usp=drivesdk">https://drive.google.com/file/d/1YXM4qQWioN3BHvuiIL9DFFapaXupqudh/view?usp=drivesdk</a> |
| Public note |
Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Clasificación local |
| Koha item type |
Documentos solicitados |
