Maintenance of CpG methylation is essential for epigenetic inheritance during plant gametogenesis (Record no. 50611)

MARC details
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fixed length control field 02514nam a2200493Ia 4500
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control field MX-MdCICY
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control field 20250625160151.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-16437
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Title Maintenance of CpG methylation is essential for epigenetic inheritance during plant gametogenesis
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Volume/sequential designation Nature Genetics, 34(1), p.65-69, 2003
520 3# - SUMMARY, ETC.
Summary, etc. In mammals, the DNA methyltransferase 1 (Dnmt1)faithfully copies the pattern of cytosine methylation at CpG sites to the newly synthesized strand, and this is essential for epigenetic inheritance1. In Arabidopsis thaliana, several DNA methyltransferases or chromatin modifiers coupled to methylation changes have been characterized, and mutations that cause loss of their function are recessive2-7. This is surprising because plant gametogenesis includes postmeiotic DNA replication in haploid nuclei before fertilization. Therefore, the recessive character of the mutations excludes the affected components from a regulatory role in postmeiotic maintenance or modification of epigenetic states. Here we show, however, that depletion of A. thaliana MET1, a homolog of mammalian Dnmt1 (ref. 8), results in immense epigenetic diversification of gametes. This diversity seems to be a consequence of passive postmeiotic demethylation, leading to gametes with fully demethylated and hemidemethylated DNA, followed by remethylation of hemimethylated templates once MET1 is again supplied in a zygote.
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Topical term or geographic name entry element ARABIDOPSIS
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Topical term or geographic name entry element ARTICLE
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Topical term or geographic name entry element CHROMATIN
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Topical term or geographic name entry element CONTROLLED STUDY
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Topical term or geographic name entry element CPG ISLAND
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Topical term or geographic name entry element DEMETHYLATION
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Topical term or geographic name entry element DNA METHYLATION
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Topical term or geographic name entry element DNA MODIFICATION
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Topical term or geographic name entry element DNA REPLICATION
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Topical term or geographic name entry element FERTILIZATION
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Topical term or geographic name entry element GAMETOGENESIS
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Topical term or geographic name entry element GENE FUNCTION
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Topical term or geographic name entry element GENE MUTATION
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Topical term or geographic name entry element GENETIC VARIABILITY
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Topical term or geographic name entry element HAPLOIDY
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Topical term or geographic name entry element HAPLOIDY
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Topical term or geographic name entry element MEIOSIS
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Topical term or geographic name entry element NONHUMAN
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Topical term or geographic name entry element NUCLEOTIDE SEQUENCE
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Topical term or geographic name entry element PRIORITY JOURNAL
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Topical term or geographic name entry element PROTEIN SYNTHESIS
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Topical term or geographic name entry element RECESSIVE INHERITANCE
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Topical term or geographic name entry element SEQUENCE ANALYSIS
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Topical term or geographic name entry element SEQUENCE HOMOLOGY
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Topical term or geographic name entry element ZYGOTE
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Personal name Saze, H.
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Personal name Scheid, O.M.
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Personal name Paszkowski, J.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1oFmmyXEV4XcpJOVmL7LWZIrVZ_j87elg/view?usp=drivesdk">https://drive.google.com/file/d/1oFmmyXEV4XcpJOVmL7LWZIrVZ_j87elg/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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Source of classification or shelving scheme Clasificación local
Koha item type Documentos solicitados
Holdings
Lost status Source of classification or shelving scheme Damaged status Not for loan Collection Home library Current library Shelving location Date acquired Total checkouts Full call number Date last seen Price effective from Koha item type
  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-16437 25.06.2025 25.06.2025 Documentos solicitados