The receptor tyrosine kinase AXL mediates nuclear translocation of the epidermal growth factor receptor (Record no. 50641)
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| fixed length control field | 02574nam a2200301Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625160152.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-16468 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | The receptor tyrosine kinase AXL mediates nuclear translocation of the epidermal growth factor receptor |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | Science Signaling, 10(460), p.DOI: 10.1126/scisignal.aag1064, 2017 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | The epidermal growth factor receptor (EGFR)is a therapeutic target in patients with various cancers. Unfortunately, resistance to EGFR-targeted therapeutics is common. Previous studies identified two mechanisms of resistance to the EGFR monoclonal antibody cetuximab. Nuclear translocation of EGFR bypasses the inhibitory effects of cetuximab, and the receptor tyrosine kinase AXL mediates cetuximab resistance by maintaining EGFR activation and downstream signaling. Thus, we hypothesized that AXL mediated the nuclear translocation of EGFR in the setting of cetuximab resistance. Cetuximab-resistant clones of non-small cell lung cancer in culture and patient-derived xenografts in mice had increased abundance of AXL and nuclear EGFR (nEGFR). Cellular fractionation analysis, super-resolution microscopy, and electron microscopy revealed that genetic loss of AXL reduced the accumulation of nEGFR. SRC family kinases (SFKs)and HER family ligands promote the nuclear translocation of EGFR. We found that AXL knockdown reduced the expression of the genes encoding the SFK family members YES and LYN and the ligand neuregulin-1 (NRG1). AXL knockdown also decreased the interaction between EGFR and the related receptor HER3 and accumulation of HER3 in the nucleus. Overexpression of LYN and NRG1 in cells depleted of AXL resulted in accumulation of nEGFR, rescuing the deficit induced by lack of AXL. Collectively, these data uncover a previously unrecognized role for AXL in regulating the nuclear translocation of EGFR and suggest that AXL-mediated SFK and NRG1 expression promote this process. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | RECEPTOR TYROSINE KINASE AXL |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Brand, T.M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Iida, M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Corrigan, K.L. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Braverman, C.M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Coan, J.P. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Flanigan, B.G. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Stein, A.P. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Stein, A.P. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rolff, J. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kimple, R.J. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wheeler, D.L. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/12zDuc4PfnH0hbs8jIc58k1PXwV8S0J63/view?usp=drivesdk">https://drive.google.com/file/d/12zDuc4PfnH0hbs8jIc58k1PXwV8S0J63/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
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| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-16468 | 25.06.2025 | 25.06.2025 | Documentos solicitados |