MARC details
| 000 -LEADER |
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| fixed length control field |
02318nam a2200289Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20250625160156.0 |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
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| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
B-16677 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT |
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| Title |
Toxic effects of crude root extract of Plumbago rosea (Rakta chitraka)on mice and rats |
| 490 0# - SERIES STATEMENT |
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| Volume/sequential designation |
Journal of EthnoPharmacology, 38(1), p.79-84, 1993 |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
The ethanolic root extract of Plumbago rosea (Plumbaginaceae)was studied for acute toxicity in mice and subacute toxicity in rats. The 24 h LD50 values of the extract in mice were 239.88 mg and 1148.15 mg/kg b. wt. for intraperitoneal and oral routes, respectively. Oral administration of doses above 1250 mg/kg produced severe diarrhea. In subacute toxicity studies no mortality was observed when 50 mg/kg of the extract was injected i.p. daily for 30 days; however, there was no weight gain in the treated rats. Significant reduction in the weights of liver, kidney, thymus and testes was observed in the male rats, while the spleen weight showed a significant increase from control. The females showed a significant loss in thymus weight and a gain in the weight of the uterus, but the liver and spleen did not show any weight change from the control. There was a significant increase in total WBC and neutrophil counts as well as in the levels of serum alkaline phosphatase and alanine transaminase (ALT)in both sexes. Similarly, the liver alkaline phosphatase level was significantly higher than control, but a significant reduction was observed in the DNA, RNA and total proteins. Thus, a higher drug dose (total dose of 15 g/kg b. wt.)was tolerated in fractionated administration, but it had a growth inhibitory effect in both sexes. The males appear to be more susceptible than females when individual organs are considered. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
ALANINE AMINOTRANSFERASE |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
ALKALINE |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
PHOSPHATASE |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
DNA |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
PLANT EXTRACT |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
PLUMBAGIN |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
PROTEIN |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
RNA |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Solomon, F.E. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Sharada, A.C. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Devi, P.U. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="https://drive.google.com/file/d/1gspN_7qvQs_sQ6HXlVHWhqOGK0wCvTvf/view?usp=drivesdk">https://drive.google.com/file/d/1gspN_7qvQs_sQ6HXlVHWhqOGK0wCvTvf/view?usp=drivesdk</a> |
| Public note |
Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Clasificación local |
| Koha item type |
Documentos solicitados |
