The Revolution Continues: Newly Discovered Systems Expand the CRISPR-Cas Toolkit (Record no. 50895)

MARC details
000 -LEADER
fixed length control field 02300nam a2200277Ia 4500
003 - CONTROL NUMBER IDENTIFIER
control field MX-MdCICY
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250625160157.0
040 ## - CATALOGING SOURCE
Transcribing agency CICY
090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN)
Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-16728
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 250602s9999 xx |||||s2 |||| ||und|d
245 10 - TITLE STATEMENT
Title The Revolution Continues: Newly Discovered Systems Expand the CRISPR-Cas Toolkit
490 0# - SERIES STATEMENT
Volume/sequential designation Molecular Cell, 68(1), p.15-25, 2017
520 3# - SUMMARY, ETC.
Summary, etc. CRISPR-Cas systems defend prokaryotes against bacteriophages and mobile genetic elements and serve as the basis for revolutionary tools for genetic engineering. Class 2 CRISPR-Cas systems use single Cas endonucleases paired with guide RNAs to cleave complementary nucleic acid targets, enabling programmable sequence-specific targeting with minimal machinery. Recent discoveries of previously unidentified CRISPR-Cas systems have uncovered a deep reservoir of potential biotechnological tools beyond the well-characterized Type II Cas9 systems. Here we review the current mechanistic understanding of newly discovered single-protein Cas endonucleases. Comparison of these Cas effectors reveals substantial mechanistic diversity, underscoring the phylogenetic divergence of related CRISPR-Cas systems. This diversity has enabled further expansion of CRISPR-Cas biotechnological toolkits, with wide-ranging applications from genome editing to diagnostic tools based on various Cas endonuclease activities. These advances highlight the exciting prospects for future tools based on the continually expanding set of CRISPR-Cas systems. CRISPR-Cas systems have been developed into revolutionary tools for genome editing and other biotechnological applications. Murugan et al. review the structure and mechanisms of recently discovered Class 2 Cas effectors and highlight the expanded applications adapted from these systems.
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element GUIDE RNA
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element NUCLEIC ACID
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element BACTERIAL PROTEIN
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element ENDONUCLEASE
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Murugan, K.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Babu, K.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Sundaresan, R.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Rajan, R.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Sashital, D.G.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1WdpezOP7vh8GP-_CyEQXu5DXmT4GNv-4/view?usp=drivesdk">https://drive.google.com/file/d/1WdpezOP7vh8GP-_CyEQXu5DXmT4GNv-4/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme Clasificación local
Koha item type Documentos solicitados
Holdings
Lost status Source of classification or shelving scheme Damaged status Not for loan Collection Home library Current library Shelving location Date acquired Total checkouts Full call number Date last seen Price effective from Koha item type
  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-16728 25.06.2025 25.06.2025 Documentos solicitados