MARC details
| 000 -LEADER |
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| fixed length control field |
02427nam a2200337Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20250625160158.0 |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
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| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
B-16813 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT |
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| Title |
Redox regulation of protein tyrosine phosphatases: Structural and chemical aspects |
| 490 0# - SERIES STATEMENT |
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| Volume/sequential designation |
Antioxidants and Redox Signaling, 15(1), p.77-97, 2011 |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
Protein tyrosine phosphatases (PTPs)are important targets of the H 2O2 that is produced during mammalian signal transduction. H2O2-mediated inactivation of PTPs also may be important in various pathophysiological conditions involving oxidative stress. Here we review the chemical and structural biology of redox-regulated PTPs. Reactions of H2O2 with PTPs convert the catalytic cysteine thiol to a sulfenic acid. In PTPs, the initially generated sulfenic acid residues have the potential to undergo secondary reactions with a neighboring amide nitrogen or cysteine thiol residue to yield a sulfenyl amide or disulfide, respectively. The chemical mechanisms by which formation of sulfenyl amide and disulfide linkages can protect the catalytic cysteine residue against irreversible overoxidation to sulfinic and sulfonic oxidation states are described. Due to the propensity for back-door and distal cysteine residues to engage with the active-site cysteine after oxidative inactivation, differences in the structures of the oxidatively inactivated PTPs may stem, to a large degree, from differences in the number and location of cysteine residues surrounding the active site of the enzymes. PTPs with key cysteine residues in structurally similar locations may be expected to share similar mechanisms of oxidative inactivation. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
AMIDE |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
CYSTEINE |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
DISULFIDE |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
HYDROGEN PEROXIDE |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
PROTEIN TYROSINE PHOSPHATASEPROTEIN TYROSINE PHOSPHATASE 1B |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
PROTEIN TYROSINE PHOSPHATASE SHP 1 |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
PROTEIN TYROSINE PHOSPHATASE SHP 2 |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
SULFENYL AMIDE |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
THIOL |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
UNCLASSIFIED DRUG |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Tanner, J.J. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Parsons, Z.D. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Cummings, A.H. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Zhou, H. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Gates, K.S. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="https://drive.google.com/file/d/1NVdbNp6HCq5efzyRAj1UErCbuNRyQNEZ/view?usp=drivesdk">https://drive.google.com/file/d/1NVdbNp6HCq5efzyRAj1UErCbuNRyQNEZ/view?usp=drivesdk</a> |
| Public note |
Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Clasificación local |
| Koha item type |
Documentos solicitados |
