Mice that express human interleukin-8 have increased mobilization of immature myeloid cells, which exacerbates inflammation and accelerates colon carcinogenesis (Record no. 51060)
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| fixed length control field | 03010nam a2200373Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625160200.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-16895 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | Mice that express human interleukin-8 have increased mobilization of immature myeloid cells, which exacerbates inflammation and accelerates colon carcinogenesis |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | Gastroenterology, 144(1), p.155-166, 2013 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | Background Aims: Interleukin (IL)-8 has an important role in initiating inflammation in humans, attracting immune cells such as neutrophils through their receptors CXCR1 and CXCR2. IL-8 has been proposed to contribute to chronic inflammation and cancer. However, mice do not have the IL-8 gene, so human cancer cell lines and xenograft studies have been used to study the role of IL-8 in colon and gastric carcinogenesis. We generated mice that carry a bacterial artificial chromosome that encompasses the entire human IL-8 gene, including its regulatory elements (IL-8Tg mice). Methods: We studied the effects of IL-8 expression in APCmin+/- mice and IL-8Tg mice given azoxymethane and dextran sodium sulfate (DSS). We also examined the effects of IL-8 expression in gastric cancer in INS-GAS mice that overexpress gastrin and IL-8Tg mice infected with Helicobacter felis. Results: In IL-8Tg mice, expression of human IL-8 was controlled by its own regulatory elements, with virtually no messenger RNA or protein detectable under basal conditions. IL-8 was strongly up-regulated on systemic or local inflammatory stimulation, increasing mobilization of immature CD11b+Gr-1+ myeloid cells (IMCs)with thioglycolate-induced peritonitis, DSS-induced colitis, and H. felis-induced gastritis. IL-8 was increased in colorectal tumors from patients and IL-8Tg mice compared with nontumor tissues. IL-8Tg mice developed more tumors than wild-type mice following administration of azoxymethane and DSS. Expression of IL-8 increased tumorigenesis in APCmin+/- mice compared with APCmin+/- mice that lack IL-8; this was associated with increased numbers of IMCs and angiogenesis in the tumors. Conclusions: IL-8 contributes to gastrointestinal carcinogenesis by mobilizing IMCs and might be a therapeutic target for gastrointestinal cancers. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | COLON CANCER |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | GASTRIC CANCER |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | IMMUNE REGULATION |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | MOUSE MODEL |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Asfaha, S. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dubeykovskiy, A.N. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Tomita, H. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Yang, X. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Stokes, S. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Shibata, W. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Friedman, R.A. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Friedman, R.A. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dubeykovskaya, Z.A. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Muthupalani, S. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ericksen, R. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Frucht, H. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Fox, J.G. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wang, T.C. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/1H8E7Kummz7Ao_acHO67tXtwFFJcy9wUr/view?usp=drivesdk">https://drive.google.com/file/d/1H8E7Kummz7Ao_acHO67tXtwFFJcy9wUr/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-16895 | 25.06.2025 | 25.06.2025 | Documentos solicitados |